Organization of conceptual tool knowledge following left and right brain lesions: Evidence from neuropsychological dissociations and multivariate disconnectome symptom mapping

IF 2.2 3区心理学 Q3 NEUROSCIENCES

Brain and Cognition Pub Date : 2024-08-31 DOI:10.1016/j.bandc.2024.106210

Mathieu Lesourd , Julie Martin , Sébastien Hague , Margolise Laroze , Gautier Clément , Alexandre Comte , Elisabeth Medeiros de Bustos , Guillaume Fargeix , Eloi Magnin , Thierry Moulin

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引用次数: 0

Abstract

The aim of this work was to better understand the organization of conceptual tool knowledge following stroke. We explored specifically the link between manipulation kinematics and manipulation hand posture; and the link between manipulation kinematics and function relations in left brain-damaged (n = 30) and right brain-damaged (n = 30) patients. We examined the performance of brain-damaged patients in conceptual tool tasks using neuropsychological dissociations and disconnectome symptom mapping. Our results suggest that manipulation kinematics is more impaired than function relations, following left or right brain lesions. We also observed that manipulation kinematics and manipulation hand posture are dissociable dimensions but are still highly interrelated, particularly in left brain-damaged patients. We also found that the corpus callosum and bilateral superior longitudinal fasciculus are involved in action and semantic tool knowledge following left brain lesions. Our results provide evidence that the right hemisphere contains conceptual tool representations. Further studies are needed to better understand the mechanisms supporting the cognitive recovery of conceptual tool knowledge. An emerging hypothesis is that the right hemisphere may support functional recovery through interhemispheric transfer following a left hemisphere stroke.

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左右脑病变后概念工具知识的组织：神经心理学差异和多变量断层症状映射的证据

这项研究旨在更好地了解中风后概念工具知识的组织。我们特别探索了左脑受损患者（30 人）和右脑受损患者（30 人）的操作运动学和操作手姿势之间的联系，以及操作运动学和功能关系之间的联系。我们利用神经心理学差异和断开症状映射检查了脑损伤患者在概念工具任务中的表现。我们的结果表明，左脑或右脑受损后，操作运动学比功能关系受损更严重。我们还观察到，操作运动学和操作手姿势是可以分离的维度，但仍然高度相关，尤其是在左脑受损患者中。我们还发现，左脑损伤后，胼胝体和双侧上纵筋束参与了动作和语义工具知识的学习。我们的研究结果提供了右半球包含概念工具表征的证据。要更好地了解支持概念工具知识认知恢复的机制，还需要进一步的研究。一个新出现的假设是，左脑中风后，右半球可能通过半球间转移支持功能恢复。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain and Cognition 医学-神经科学

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Brain and Cognition is a forum for the integration of the neurosciences and cognitive sciences. B&C publishes peer-reviewed research articles, theoretical papers, case histories that address important theoretical issues, and historical articles into the interaction between cognitive function and brain processes. The focus is on rigorous studies of an empirical or theoretical nature and which make an original contribution to our knowledge about the involvement of the nervous system in cognition. Coverage includes, but is not limited to memory, learning, emotion, perception, movement, music or praxis in relationship to brain structure or function. Published articles will typically address issues relating some aspect of cognitive function to its neurological substrates with clear theoretical import, formulating new hypotheses or refuting previously established hypotheses. Clinical papers are welcome if they raise issues of theoretical importance or concern and shed light on the interaction between brain function and cognitive function. We welcome review articles that clearly contribute a new perspective or integration, beyond summarizing the literature in the field; authors of review articles should make explicit where the contribution lies. We also welcome proposals for special issues on aspects of the relation between cognition and the structure and function of the nervous system. Such proposals can be made directly to the Editor-in-Chief from individuals interested in being guest editors for such collections.