Effects of a pH-Regulating Emollient Cream in Mild Atopic Dermatitis Patients with Moderate Localized Lesions.

IF 2.8 4区 医学 Q2 DERMATOLOGY
Skin Pharmacology and Physiology Pub Date : 2024-01-01 Epub Date: 2024-08-28 DOI:10.1159/000541022
Sue Phay Ng, Stephan Bielfeldt, Sabrina Laing, Simon Danby, Michael J John Cork
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引用次数: 0

Abstract

Introduction: Increased skin pH values in patients with atopic dermatitis (AD) contribute to poor antimicrobial and permeability barrier functions of the skin. In practice, the majority of topical preparations available for dry skin conditions do not provide sufficient pH and buffering capacity for maintaining optimum skin surface conditions. To address this issue, we tested a novel zinc lactobionate preparation to determine whether the regular application would lower skin surface pH, and in doing so improve the condition of lesional skin.

Methods: The assessment for local severity of AD was done with the Scoring Atopic Dermatitis Index (SCORAD) and skin dryness was assessed by capacitance measurement.

Results: The results showed that the test product lowered skin pH and improved AD skin lesions from moderate to mild during 2 weeks of application. In the treated area a lowered pH of about 0.85 units was found. Together with the lowering of pH, the local SCORAD significantly improved from 8.3 on average down to 4.0, while in the untreated area, only a slight improvement (from 8.2 to 6.4) was found.

Conclusion: Synergistic effects of the test product's pH lowering and emollient properties might explain the observed improvements in clinical signs of AD and further research against a comparator would allow the specific contribution of pH modulation to these improvements to be unambiguously isolated.

调节 pH 值的润肤霜对局部中度病变的轻度特应性皮炎患者的影响
导言:特应性皮炎(AD)患者皮肤 pH 值升高会导致皮肤抗菌和渗透屏障功能低下。实际上,大多数治疗干性皮肤病的外用制剂并不能提供足够的 pH 值和缓冲能力来维持皮肤表面的最佳状态。为了解决这个问题,我们测试了一种新型乳糖酸锌制剂,以确定定期使用是否会降低皮肤表面的 pH 值,从而改善病变皮肤的状况:方法:用 SCORAD 评估 AD 的局部严重程度,用电容测量法评估皮肤干燥程度:结果表明,试验产品能降低皮肤的 pH 值,并在使用 2 周后将特应性皮炎的皮损从中度改善为轻度。在接受治疗的部位,pH 值降低了约 0.85 个单位。在降低 pH 值的同时,局部的 SCORAD 值也得到了显著改善,从平均值 8.3 降至 4.0,而未治疗部位的 SCORAD 值仅有轻微改善(从 8.2 降至 6.4):试验产品的 pH 值降低和润肤特性的协同作用可能是所观察到的 AD 临床症状得到改善的原因,而针对对比试验的进一步研究将能明确区分 pH 值调节对这些改善的具体作用。
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来源期刊
Skin Pharmacology and Physiology
Skin Pharmacology and Physiology 医学-皮肤病学
CiteScore
5.20
自引率
7.40%
发文量
23
审稿时长
>12 weeks
期刊介绍: In the past decade research into skin pharmacology has rapidly developed with new and promising drugs and therapeutic concepts being introduced regularly. Recently, the use of nanoparticles for drug delivery in dermatology and cosmetology has become a topic of intensive research, yielding remarkable and in part surprising results. Another topic of current research is the use of tissue tolerable plasma in wound treatment. Stimulating not only wound healing processes but also the penetration of topically applied substances into the skin, this novel technique is expected to deliver very interesting results.
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