Gestational diabetes mellitus and development of intergenerational overall and subtypes of cardiovascular diseases: a systematic review and meta-analysis.

IF 8.5 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Diabetology Pub Date : 2024-08-28 DOI:10.1186/s12933-024-02416-7

Ashley Chen, Breanna Tan, Ruochen Du, Yap Seng Chong, Cuilin Zhang, Angela S Koh, Ling-Jun Li

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引用次数: 0

Abstract

Objective: We aimed to summarize the association between gestational diabetes mellitus (GDM) and its intergenerational cardiovascular diseases (CVDs) impacts in both mothers and offspring post-delivery in existing literature.

Methods: PubMed, Embase, Web of Science, and Scopus were utilized for searching publications between January 1980 and June 2024, with data extraction and meta-analysis continuing until 31 July 2024. Based on a predefined PROSPERO protocol, studies published as full-length, English-language journal articles that reported the presence of GDM during pregnancy and its association with any CVD development post-delivery were selected. All studies were evaluated using the Newcastle-Ottawa Scale. Maximally adjusted risk estimates were pooled using random-effects meta-analysis to assess the risk ratio (RR) of GDM, and overall and subtypes of CVDs in both mothers and offspring post-delivery.

Results: The meta-analysis was based on 38 studies with a total of 77,678,684 participants. The results showed a 46% increased risk (RR 1.46, 95% CI 1.34-1.59) for mothers and a 23% increased risk (1.23, 1.05-1.45) for offspring of developing overall CVDs after delivery, following a GDM-complicated pregnancy. Our subgroup analysis revealed that mothers with a history of GDM faced various risks (20% to 2-fold) of developing different subtypes of CVDs, including cerebrovascular disease, coronary artery disease, heart failure, and venous thromboembolism.

Conclusions: These findings underscore the heightened risk of developing various CVDs for mothers and offspring affected by GDM, emphasizing the importance of preventive measures even right after birth to mitigate the burden of CVDs in these populations.

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妊娠糖尿病与心血管疾病的代际总体和亚型发展：系统回顾和荟萃分析。

目的：我们的目的是总结现有文献中妊娠期糖尿病（GDM）与其对母婴产后心血管疾病（CVDs）的代际影响之间的关系：利用PubMed、Embase、Web of Science和Scopus检索1980年1月至2024年6月期间的出版物，数据提取和荟萃分析持续到2024年7月31日。根据预先确定的 PROSPERO 方案，筛选出以英文期刊论文形式发表的、报道孕期 GDM 存在及其与产后心血管疾病发展相关性的研究。所有研究均采用纽卡斯尔-渥太华量表进行评估。采用随机效应荟萃分析法对最大调整风险估计值进行汇总，以评估GDM的风险比（RR）以及母亲和后代产后心血管疾病的总体和亚型：荟萃分析基于 38 项研究，共有 77 678 684 人参与。结果显示，GDM 并发症妊娠的母亲和后代在分娩后患心血管疾病的风险分别增加了 46%（RR 1.46，95% CI 1.34-1.59）和 23%（1.23，1.05-1.45）。我们的亚组分析显示，有GDM病史的母亲患不同亚型心血管疾病的风险不同（20%至2倍），包括脑血管疾病、冠状动脉疾病、心力衰竭和静脉血栓栓塞：这些研究结果表明，受 GDM 影响的母亲和后代罹患各种心血管疾病的风险增加，这就强调了采取预防措施的重要性，即使是在孩子出生后也应采取预防措施，以减轻心血管疾病给这些人群带来的负担。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiovascular Diabetology 医学-内分泌学与代谢

CiteScore

12.30

自引率

15.10%

发文量

240

审稿时长

1 months

期刊介绍： Cardiovascular Diabetology is a journal that welcomes manuscripts exploring various aspects of the relationship between diabetes, cardiovascular health, and the metabolic syndrome. We invite submissions related to clinical studies, genetic investigations, experimental research, pharmacological studies, epidemiological analyses, and molecular biology research in this field.