lncRNA TUG1 transcript levels and psychological disorders: insights into interplay of glycemic index and glycemic load.

IF 2.1 4区 医学 Q3 GENETICS & HEREDITY
Niloufar Rasaei, Fataneh Esmaeili, Alireza Khadem, Mir Saeed Yekaninejad, Khadijeh Mirzaei
{"title":"lncRNA TUG1 transcript levels and psychological disorders: insights into interplay of glycemic index and glycemic load.","authors":"Niloufar Rasaei, Fataneh Esmaeili, Alireza Khadem, Mir Saeed Yekaninejad, Khadijeh Mirzaei","doi":"10.1186/s12920-024-01976-7","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>There is an association between obesity and psychological disorders such as depression, anxiety, and stress. Environmental factors and genetics play a crucial role in this regard. Several long non-coding RNAs (lncRNAs) are involved in the pathophysiology of the nervous system. Additionally, we intend to investigate how dietary glycemic index and load relate to psychological disorders in women with obesity and overweight by identifying the possible interaction with metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and taurine upregulated gene 1 (TUG1).</p><p><strong>Methods: </strong>267 overweight or obese women between the ages of 18 and 48 were recruited for the current study. A reliable and validated food frequency questionnaire (FFQ) consisting of 147 items assessed food consumption, glycemic load (GL), and glycemic index (GI). Depression-Anxiety-Stress Scales (DASS-21) were used to assess mental well-being. A real-time polymerase chain reaction (PCR) was used to assess transcript levels for lncRNAs MALAT1 and TUG1.</p><p><strong>Results: </strong>In obese and overweight women, a positive correlation was found between anxiety and MALAT1 mRNA levels (P = 0.007, CC = 0.178). Age, energy intake, physical activity, total fat, income, marriage, thyroid, and BMI were adjusted, and GI and TUG1 were positively correlated on DASS-21 (β = 0.006, CI = 0.001, 0.01, P = 0.031), depression (β = 0.002, CI = 0.001, 0.004, P = 0.019), Stress (β = 0.003, CI = 0.001, 0.005, P = 0.027). The interaction of GL and TUG1 on stress was also observed (β = 0.03, CI = 0.001, 0.07, P = 0.048).</p><p><strong>Conclusions: </strong>The lncRNA TUG1 appears to be associated with depression and stress through interaction with GI and correlated with stress by interaction with GL. To establish this concept, further research is required.</p>","PeriodicalId":8915,"journal":{"name":"BMC Medical Genomics","volume":null,"pages":null},"PeriodicalIF":2.1000,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11351548/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Medical Genomics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12920-024-01976-7","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: There is an association between obesity and psychological disorders such as depression, anxiety, and stress. Environmental factors and genetics play a crucial role in this regard. Several long non-coding RNAs (lncRNAs) are involved in the pathophysiology of the nervous system. Additionally, we intend to investigate how dietary glycemic index and load relate to psychological disorders in women with obesity and overweight by identifying the possible interaction with metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and taurine upregulated gene 1 (TUG1).

Methods: 267 overweight or obese women between the ages of 18 and 48 were recruited for the current study. A reliable and validated food frequency questionnaire (FFQ) consisting of 147 items assessed food consumption, glycemic load (GL), and glycemic index (GI). Depression-Anxiety-Stress Scales (DASS-21) were used to assess mental well-being. A real-time polymerase chain reaction (PCR) was used to assess transcript levels for lncRNAs MALAT1 and TUG1.

Results: In obese and overweight women, a positive correlation was found between anxiety and MALAT1 mRNA levels (P = 0.007, CC = 0.178). Age, energy intake, physical activity, total fat, income, marriage, thyroid, and BMI were adjusted, and GI and TUG1 were positively correlated on DASS-21 (β = 0.006, CI = 0.001, 0.01, P = 0.031), depression (β = 0.002, CI = 0.001, 0.004, P = 0.019), Stress (β = 0.003, CI = 0.001, 0.005, P = 0.027). The interaction of GL and TUG1 on stress was also observed (β = 0.03, CI = 0.001, 0.07, P = 0.048).

Conclusions: The lncRNA TUG1 appears to be associated with depression and stress through interaction with GI and correlated with stress by interaction with GL. To establish this concept, further research is required.

lncRNA TUG1转录水平与心理障碍:对血糖指数和血糖负荷相互作用的见解。
背景:肥胖与抑郁、焦虑和压力等心理疾病之间存在关联。环境因素和遗传在这方面起着至关重要的作用。一些长非编码 RNA(lncRNA)与神经系统的病理生理学有关。此外,我们还打算通过确定与转移相关肺腺癌转录本 1(MALAT1)和牛磺酸上调基因 1(TUG1)之间可能存在的相互作用,研究膳食血糖生成指数和负荷与肥胖和超重女性心理障碍之间的关系。由 147 个项目组成的可靠、有效的食物频率问卷(FFQ)评估了食物消耗量、血糖负荷(GL)和血糖指数(GI)。抑郁-焦虑-压力量表(DASS-21)用于评估心理健康状况。实时聚合酶链反应(PCR)用于评估 lncRNAs MALAT1 和 TUG1 的转录水平:结果:在肥胖和超重女性中,焦虑与 MALAT1 mRNA 水平呈正相关(P = 0.007,CC = 0.178)。调整年龄、能量摄入、体力活动、总脂肪、收入、婚姻、甲状腺和体重指数后,GI 和 TUG1 在 DASS-21 (β = 0.006,CI = 0.001,0.01,P = 0.031)、抑郁(β = 0.002,CI = 0.001,0.004,P = 0.019)、应激(β = 0.003,CI = 0.001,0.005,P = 0.027)方面呈正相关。还观察到 GL 和 TUG1 对压力的交互作用(β = 0.03,CI = 0.001,0.07,P = 0.048):lncRNA TUG1似乎通过与GI的相互作用与抑郁和压力相关,通过与GL的相互作用与压力相关。要确立这一概念,还需要进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
BMC Medical Genomics
BMC Medical Genomics 医学-遗传学
CiteScore
3.90
自引率
0.00%
发文量
243
审稿时长
3.5 months
期刊介绍: BMC Medical Genomics is an open access journal publishing original peer-reviewed research articles in all aspects of functional genomics, genome structure, genome-scale population genetics, epigenomics, proteomics, systems analysis, and pharmacogenomics in relation to human health and disease.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信