Retrospective, propensity score--matched study examining the relationship between frailty and Clostridioides difficile infection in a national cohort of US veterans.

IF 3.8 3区医学 Q2 INFECTIOUS DISEASES

American journal of infection control Pub Date : 2024-08-26 DOI:10.1016/j.ajic.2024.08.020

Kelly R Reveles, Kelsey A Strey, Esther L Albuquerque, Damaris Jacota, Xavier Jones, Joseph J Carreno

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引用次数: 0

Abstract

Background: Frailty is often more predictive of disease and mortality compared with chronological age. This study determined the impact of frailty on Clostridioides difficile infection (CDI) risk and outcomes in a national veteran population.

Methods: This was a retrospective cohort study of CDI and control veteran inpatients and outpatients from fiscal year 2003 to 2018. Baseline frailty was presented as the Veterans Affairs (VA) Frailty Index. Propensity score--matched analyses were conducted to compare CDI risk, CDI health outcomes, and 1-year new-onset frailty-associated conditions.

Results: A total of 11,451 CDI and 11,451 matched control patients were included. Baseline frailty conditions were more common among CDI patients, especially involuntary weight loss (6.0% vs 3.4%, P < .001) and anemia (24.6% vs 18.7%, P < .001). VA Frailty Index was significantly higher for CDI patients (0.13 vs 0.11, P = .019). Frail CDI patients were more likely to experience 30-day mortality (11.3% vs 1.1%, P < .001) and 60-day CDI recurrence (20.4% vs 16.3%, P < .001) compared with non-/prefrail CDI patients. At 1year, CDI patients were significantly more likely to be categorized as frail (19.6% vs 17.0%, P < .001).

Conclusions: This study demonstrated the potential association between frailty and CDI risk and health outcomes, as well as new-onset frailty diagnoses in patients who develop CDI.

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在美国退伍军人全国队列中开展倾向得分匹配回顾性研究，探讨虚弱与艰难梭菌感染之间的关系。

背景：与实际年龄相比，虚弱通常更能预测疾病和死亡率。本研究确定了全国退伍军人群体中体弱对 CDI 风险和结果的影响：这是一项回顾性队列研究，研究对象为 2003-2018 财年的 CDI 和对照组退伍军人住院和门诊患者。基线虚弱度以退伍军人虚弱指数（VA-FI）表示。研究人员进行了一系列倾向得分匹配分析，以比较 CDI 风险、CDI 健康结果和一年内新发的虚弱相关病症：结果：共纳入了 11,451 名 CDI 患者和 11,451 名匹配对照组患者。基线虚弱状况在 CDI 患者中更为常见，尤其是非自愿性体重减轻（6.0% 对 3.4%，p）：这项研究证明了基线虚弱与 CDI 风险和健康结果之间的潜在联系，以及 CDI 患者中新出现的虚弱诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of infection control 医学-传染病学

CiteScore

7.40

自引率

4.10%

发文量

479

审稿时长

24 days

期刊介绍： AJIC covers key topics and issues in infection control and epidemiology. Infection control professionals, including physicians, nurses, and epidemiologists, rely on AJIC for peer-reviewed articles covering clinical topics as well as original research. As the official publication of the Association for Professionals in Infection Control and Epidemiology (APIC)