Retrospective, propensity score--matched study examining the relationship between frailty and Clostridioides difficile infection in a national cohort of US veterans

IF 3.8 3区医学 Q2 INFECTIOUS DISEASES

American journal of infection control Pub Date : 2024-08-26 DOI:10.1016/j.ajic.2024.08.020

Kelly R. Reveles PharmD, PhD , Kelsey A. Strey PharmD , Esther L. Albuquerque , Damaris Jacota , Xavier Jones BS , Joseph J. Carreno PharmD, MPH

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引用次数: 0

Abstract

Background

Frailty is often more predictive of disease and mortality compared with chronological age. This study determined the impact of frailty on Clostridioides difficile infection (CDI) risk and outcomes in a national veteran population.

Methods

This was a retrospective cohort study of CDI and control veteran inpatients and outpatients from fiscal year 2003 to 2018. Baseline frailty was presented as the Veterans Affairs (VA) Frailty Index. Propensity score--matched analyses were conducted to compare CDI risk, CDI health outcomes, and 1-year new-onset frailty-associated conditions.

Results

A total of 11,451 CDI and 11,451 matched control patients were included. Baseline frailty conditions were more common among CDI patients, especially involuntary weight loss (6.0% vs 3.4%, P < .001) and anemia (24.6% vs 18.7%, P < .001). VA Frailty Index was significantly higher for CDI patients (0.13 vs 0.11, P = .019). Frail CDI patients were more likely to experience 30-day mortality (11.3% vs 1.1%, P < .001) and 60-day CDI recurrence (20.4% vs 16.3%, P < .001) compared with non-/prefrail CDI patients. At 1 year, CDI patients were significantly more likely to be categorized as frail (19.6% vs 17.0%, P < .001).

Conclusions

This study demonstrated the potential association between frailty and CDI risk and health outcomes, as well as new-onset frailty diagnoses in patients who develop CDI.

查看原文本刊更多论文

在美国退伍军人全国队列中开展倾向得分匹配回顾性研究，探讨虚弱与艰难梭菌感染之间的关系。

背景：与实际年龄相比，虚弱通常更能预测疾病和死亡率。本研究确定了全国退伍军人群体中体弱对 CDI 风险和结果的影响：这是一项回顾性队列研究，研究对象为 2003-2018 财年的 CDI 和对照组退伍军人住院和门诊患者。基线虚弱度以退伍军人虚弱指数（VA-FI）表示。研究人员进行了一系列倾向得分匹配分析，以比较 CDI 风险、CDI 健康结果和一年内新发的虚弱相关病症：结果：共纳入了 11,451 名 CDI 患者和 11,451 名匹配对照组患者。基线虚弱状况在 CDI 患者中更为常见，尤其是非自愿性体重减轻（6.0% 对 3.4%，p）：这项研究证明了基线虚弱与 CDI 风险和健康结果之间的潜在联系，以及 CDI 患者中新出现的虚弱诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of infection control 医学-传染病学

CiteScore

7.40

自引率

4.10%

发文量

479

审稿时长

24 days

期刊介绍： AJIC covers key topics and issues in infection control and epidemiology. Infection control professionals, including physicians, nurses, and epidemiologists, rely on AJIC for peer-reviewed articles covering clinical topics as well as original research. As the official publication of the Association for Professionals in Infection Control and Epidemiology (APIC)