The GLCCI1/STAT3 pathway: a novel pathway involved in diabetic cognitive dysfunction and the therapeutic effect of salidroside

IF 2.9 4区生物学 Q3 CELL BIOLOGY

Journal of Molecular Histology Pub Date : 2024-08-29 DOI:10.1007/s10735-024-10236-y

Lin Niu, Min Xu, Wenqiang Liu, Hongdan Yu, Shengxue Yu, Fuzhi Li, Teng Wang, Die Sun, Tiefeng Yao, Wanze Li, Zhengzhong Yang, Xuezheng Liu, Zhongfu Zuo

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引用次数: 0

Abstract

Diabetic cognitive dysfunction (DCD) is a complication of diabetes that seriously affects quality of life. Glucocorticoid-induced transcript 1 (GLCCI1) has been found to be involved in inflammation, apoptosis and autophagy in various diseases. However, the distribution of GLCCI1 in the brain and its role in DCD have not yet been revealed. In addition, the potential therapeutics effects of salidroside (SAL), a phenyl propyl glycoside compound known for its neuroprotective effects in treating DCD are unknow. In the present study, we found that GLCCI1 was localized in hippocampal neurons. C57BL/6 J mice with DCD presented downregulation of GLCCI1 and Bcl-2 and upregulation of p-STAT3/STAT3, Bax, Cleaved Caspase-3/Caspase-3. Overexpression of GLCCI1 or SAL administration relieved DCD, reversed the changes in the expression of these cytokines, and alleviated morphological alterations in hippocampal neurons. Interestingly, SAL alleviated DCD and attenuated the expression of GLCCI1 and p-STAT3, showing similar effects as GLCCI1 overexpression. These findings suggest that the GLCCI1/STAT3 axis plays a crucial role in DCD and is involved in SAL-mediated attenuation of DCD.

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GLCCI1/STAT3通路：参与糖尿病认知功能障碍和水杨甙治疗效果的新通路。

糖尿病认知功能障碍（DCD）是严重影响生活质量的糖尿病并发症。糖皮质激素诱导转录本1（GLCCI1）被发现参与了多种疾病的炎症、细胞凋亡和自噬过程。然而，GLCCI1 在大脑中的分布及其在 DCD 中的作用尚未被揭示。此外，以治疗 DCD 而闻名的苯丙基糖苷化合物沙利度苷（Salidroside，SAL）在神经保护方面的潜在治疗作用也尚不清楚。在本研究中，我们发现 GLCCI1 定位于海马神经元。C57BL/6 J DCD小鼠的GLCCI1和Bcl-2下调，p-STAT3/STAT3、Bax、裂解Caspase-3/Caspase-3上调。过表达 GLCCI1 或服用 SAL 可缓解 DCD，逆转这些细胞因子的表达变化，并减轻海马神经元的形态学改变。有趣的是，SAL缓解了DCD，并减轻了GLCCI1和p-STAT3的表达，显示出与GLCCI1过表达相似的效果。这些研究结果表明，GLCCI1/STAT3轴在DCD中起着至关重要的作用，并参与了SAL介导的DCD衰减。

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来源期刊

Journal of Molecular Histology 生物-细胞生物学

CiteScore

5.90

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Molecular Histology publishes results of original research on the localization and expression of molecules in animal cells, tissues and organs. Coverage includes studies describing novel cellular or ultrastructural distributions of molecules which provide insight into biochemical or physiological function, development, histologic structure and disease processes. Major research themes of particular interest include: - Cell-Cell and Cell-Matrix Interactions; - Connective Tissues; - Development and Disease; - Neuroscience. Please note that the Journal of Molecular Histology does not consider manuscripts dealing with the application of immunological or other probes on non-standard laboratory animal models unless the results are clearly of significant and general biological importance. The Journal of Molecular Histology publishes full-length original research papers, review articles, short communications and letters to the editors. All manuscripts are typically reviewed by two independent referees. The Journal of Molecular Histology is a continuation of The Histochemical Journal.