Stability of metal ion complexes with the synthetic phytosiderophore proline-2'-deoxymugineic acid.

IF 4.1 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Anna Evers, Jackson Kohn, Oliver Baars, James M Harrington, Kosuke Namba, Owen W Duckworth
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Abstract

Adequate micronutrient concentrations in crops are essential for human health and agricultural productivity. However, 30% of plants growing on cultivated soils worldwide are deficient in iron (Fe). Because of low micronutrient bioavailability, graminaceous plants have evolved to exude small molecules, called phytosiderophores, into the soil environment, which strongly complex and promote uptake of trace elements. The development of a synthetic phytosiderophore, proline-2'-deoxymugeneic acid (PDMA), has been shown to promote Fe uptake in rice plants; however, its binding capabilities with other metals, which may impact the ability to promote the uptake of Fe and other trace nutrient metals commonly found in soils, remain unknown. We conducted spectrophotometric titrations to determine the stability constants (logK) of PDMA complexes with Mn(II), Co(II), Cu(II), Ni(II), and Zn(II). We determined that PDMA complex stability constants correlated with: (1) the hydrolysis constants of metal ions (logKOH) in complexes; (2) the ionic potential of complexed metals; and (3) the corresponding complex stability constants of other mugineic acid type phytosiderophores, as well as the trishydroxamate microbial siderophore DFOB. These correlations demonstrate the potential, and limitations, on our ability to predict the stability of phytosiderophore complexes with metal ions with different physicochemical properties and with potentially different coordination structures.

Abstract Image

金属离子与合成植物苷酸脯氨酸-2'-脱氧木精酸复合物的稳定性。
作物中充足的微量营养元素对人类健康和农业生产力至关重要。然而,全球 30% 的耕地植物缺铁(Fe)。由于微量元素的生物利用率较低,禾本科植物在进化过程中向土壤环境中渗出了被称为植物苷元的小分子,这些小分子具有很强的复合性,能促进微量元素的吸收。人工合成的植物苷元--脯氨酸-2'-脱氧木精酸(PDMA)已被证明能促进水稻植物对铁的吸收;然而,它与其他金属的结合能力可能会影响对土壤中常见的铁和其他痕量营养金属的吸收能力,这一点仍然不得而知。我们进行了分光光度滴定,以确定 PDMA 与锰(II)、钴(II)、铜(II)、镍(II)和锌(II)复合物的稳定性常数(logK)。我们确定 PDMA 复合物的稳定常数与下列因素相关(1) 配合物中金属离子的水解常数(logKOH);(2) 配合物金属的离子电位;(3) 其他艾氏酸型植物苷元以及三羟基氨基甲酸酯微生物苷元 DFOB 的相应配合物稳定常数。这些相关性表明,我们在预测植物苷元与具有不同理化性质和潜在不同配位结构的金属离子的络合物稳定性方面具有潜力和局限性。
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来源期刊
Biometals
Biometals 生物-生化与分子生物学
CiteScore
5.90
自引率
8.60%
发文量
111
审稿时长
3 months
期刊介绍: BioMetals is the only established journal to feature the important role of metal ions in chemistry, biology, biochemistry, environmental science, and medicine. BioMetals is an international, multidisciplinary journal singularly devoted to the rapid publication of the fundamental advances of both basic and applied research in this field. BioMetals offers a forum for innovative research and clinical results on the structure and function of: - metal ions - metal chelates, - siderophores, - metal-containing proteins - biominerals in all biosystems. - BioMetals rapidly publishes original articles and reviews. BioMetals is a journal for metals researchers who practice in medicine, biochemistry, pharmacology, toxicology, microbiology, cell biology, chemistry, and plant physiology who are based academic, industrial and government laboratories.
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