Static compression optical coherence elastography for the measurement of porcine corneal mechanical properties ex-vivo

IF 5.3 2区医学 Q1 ENGINEERING, BIOMEDICAL

Biocybernetics and Biomedical Engineering Pub Date : 2024-07-01 DOI:10.1016/j.bbe.2024.08.006

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引用次数: 0

Abstract

Significance

The biomechanical properties of the cornea are important for vision and ocular health. Optical coherence elastography (OCE) has the potential to improve our capacity to measure these properties.

Aim

This study tested a static compression OCE method utilising a commercially available optical coherence tomography (OCT) device, to estimate the Young’s modulus of ex-vivo porcine corneal tissue.

Approach: OCT was used to image corneal tissue samples before and during loading by static compression. The compressive force was measured with a piezoresistive force sensor, and tissue deformation was quantified through automated image analysis. Ten ex-vivo porcine corneas were assessed and the corneal thickness was also measured to assess the impact of corneal swelling.

Results

An average (standard deviation) Young’s modulus of 0.271 (+/- 0.091) MPa was determined across the 10 corneas assessed. There was a mean decrease of 1.78 % in corneal thickness at the end of the compression series. These results showed that there was a moderate association between corneal thickness and the Young’s modulus recording (R² = 0.274).

Conclusions

Optical coherence elastography utilising clinical instrumentation, can reliably characterise the mechanical properties of the cornea. These results support the further investigation of the technique for in-vivo measurement of the mechanical properties of the human cornea.

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用静态压缩光学相干弹性成像技术测量猪角膜的体外机械特性

意义角膜的生物力学特性对视力和眼部健康非常重要。本研究测试了一种利用市售光学相干断层扫描（OCT）设备进行静态压缩的 OCE 方法，以估算活体猪角膜组织的杨氏模量：方法：在静态压缩加载前和加载过程中，使用光学相干断层扫描对角膜组织样本进行成像。利用压阻力传感器测量压缩力，并通过自动图像分析量化组织变形。对 10 个活体猪角膜进行了评估，并测量了角膜厚度，以评估角膜肿胀的影响。结果在评估的 10 个角膜中，测定的平均（标准偏差）杨氏模量为 0.271 (+/- 0.091) MPa。压迫系列结束时，角膜厚度平均减少了 1.78%。这些结果表明，角膜厚度与杨氏模量记录（R2 = 0.274）之间存在适度关联。这些结果支持进一步研究体内测量人类角膜机械特性的技术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biocybernetics and Biomedical Engineering ENGINEERING, BIOMEDICAL-

CiteScore

16.50

自引率

6.20%

发文量

审稿时长

38 days

期刊介绍： Biocybernetics and Biomedical Engineering is a quarterly journal, founded in 1981, devoted to publishing the results of original, innovative and creative research investigations in the field of Biocybernetics and biomedical engineering, which bridges mathematical, physical, chemical and engineering methods and technology to analyse physiological processes in living organisms as well as to develop methods, devices and systems used in biology and medicine, mainly in medical diagnosis, monitoring systems and therapy. The Journal''s mission is to advance scientific discovery into new or improved standards of care, and promotion a wide-ranging exchange between science and its application to humans.