Lighting up industrial mechanochemistry: Real-time in situ monitoring of reactive extrusion using energy-dispersive X-ray diffraction

IF 19.1 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Chem Pub Date : 2024-11-14 DOI:10.1016/j.chempr.2024.07.033

Nikita Y. Gugin , Kirill V. Yusenko , Andrew King , Klas Meyer , Dominik Al-Sabbagh , Jose A. Villajos , Franziska Emmerling

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Abstract

Mechanochemistry is an environmentally friendly synthetic approach that enables the sustainable production of a wide range of chemicals while reducing or eliminating the need for solvents. Reactive extrusion aims to move mechanochemistry from its conventional gram-scale batch reactions, typically performed in laboratory ball mills, to a continuous, large-scale process. Meeting this challenge requires in situ monitoring techniques to gain insights into reactive extrusion and its underlying processes. While the effectiveness of in situ Raman spectroscopy in providing molecular-level information has been demonstrated, our study uses energy-dispersive X-ray diffraction to monitor reactive extrusion in real time at the crystalline level. Our results provide previously unavailable control over the reactive extrusion process, promoting its perception as an industrially feasible green alternative to traditional solvent-based syntheses.

Video abstract

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点亮工业机械化学：利用能量色散 X 射线衍射对反应挤压进行实时原位监测

机械化学是一种环境友好型合成方法，可实现多种化学品的可持续生产，同时减少或消除对溶剂的需求。反应挤压法旨在将机械化学从传统的克级批量反应（通常在实验室球磨机中进行）转变为连续的大规模工艺。要应对这一挑战，需要采用原位监测技术来深入了解反应挤压及其基本过程。虽然原位拉曼光谱在提供分子级信息方面的有效性已得到证实，但我们的研究利用能量色散 X 射线衍射技术在晶体级实时监测反应挤压。我们的研究结果提供了以前无法获得的对反应性挤压过程的控制，促进了人们对反应性挤压作为传统溶剂型合成的一种工业上可行的绿色替代方法的认识。视频摘要下载：下载视频 (18MB)

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来源期刊

Chem Environmental Science-Environmental Chemistry

CiteScore

32.40

自引率

1.30%

发文量

281

期刊介绍： Chem, affiliated with Cell as its sister journal, serves as a platform for groundbreaking research and illustrates how fundamental inquiries in chemistry and its related fields can contribute to addressing future global challenges. It was established in 2016, and is currently edited by Robert Eagling.