Visible‐Light‐Initiated Uranyl‐Catalyzed Hydrosilylation and Hydrosulfonylation of Alkenes and Alkynes

IF 4.4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2025-02-18 DOI:10.1002/adsc.202400745

Xingxing Gong , Qianyi Zhao , Congqing Zhu

引用次数: 0

Abstract

This study investigates the visible‐light‐initiated uranyl(VI)‐catalyzed activation of Si−H bonds through direct hydrogen atom transfer, which facilitates the formation of silyl radicals from silanes. The silyl radical can abstract a chlorine atom from the sulfonyl chloride, leading to the generation of sulfonyl radicals. These silyl radicals and sulfonyl radicals could react with alkenes and alkynes, achieving the first example of uranyl‐catalyzed hydrosilylation and hydrosulfonylation of unsaturated C−C bonds. This method features mild reaction conditions and a broad substrate scope, and exhibits exceptional functional‐group tolerance. Consequently, it is suitable for the late‐stage functionalization of drug derivatives.

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可见光引发的铀催化烯烃和炔烃的氢硅烷化和氢磺酰化反应

本研究探讨了可见光引发的铀酰（VI）催化活化 Si-H 键的过程，该过程通过直接氢原子转移促进硅烷中硅烷基的形成。硅烷基可从磺酰氯中抽取一个氯原子，从而生成磺酰基。这些硅基和磺酰基可与烯烃和炔烃发生反应，首次实现了铀酰催化的不饱和 C-C 键的氢硅化和氢磺化反应。这种方法的特点是反应条件温和，底物范围广泛，对官能团的耐受性极强。因此，它适用于药物衍生物的后期官能化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.