Organocatalytic acylation of remote arene C–H bonds

IF 42.8 1区化学 Q1 CHEMISTRY, PHYSICAL

Nature Catalysis Pub Date : 2024-08-27 DOI:10.1038/s41929-024-01195-4

引用次数: 0

Abstract

Site-selective acylation of remote arene C(sp2)−H bonds is achieved through N-heterocyclic carbene organocatalysis. This catalytic transformation proceeds through a nitrogen radical-mediated pathway and enables the late-stage modification of drugs, amino acids and peptides under mild conditions.

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远端芳烃 C-H 键的有机催化酰化反应

通过 N-杂环碳烯有机催化实现了远端芳烃 C(sp2)-H 键的位点选择性酰化。这种催化转化通过氮自由基介导的途径进行，可在温和的条件下对药物、氨基酸和肽进行后期修饰。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Catalysis Chemical Engineering-Bioengineering

CiteScore

52.10

自引率

1.10%

发文量

140

期刊介绍： Nature Catalysis serves as a platform for researchers across chemistry and related fields, focusing on homogeneous catalysis, heterogeneous catalysis, and biocatalysts, encompassing both fundamental and applied studies. With a particular emphasis on advancing sustainable industries and processes, the journal provides comprehensive coverage of catalysis research, appealing to scientists, engineers, and researchers in academia and industry. Maintaining the high standards of the Nature brand, Nature Catalysis boasts a dedicated team of professional editors, rigorous peer-review processes, and swift publication times, ensuring editorial independence and quality. The journal publishes work spanning heterogeneous catalysis, homogeneous catalysis, and biocatalysis, covering areas such as catalytic synthesis, mechanisms, characterization, computational studies, nanoparticle catalysis, electrocatalysis, photocatalysis, environmental catalysis, asymmetric catalysis, and various forms of organocatalysis.