Association of epicardial adipose tissue on magnetic resonance imaging with cardiovascular outcomes: Quality over quantity?

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Obesity Pub Date : 2024-08-28 DOI:10.1002/oby.24105

Franz Duca, Katharina Mascherbauer, Carolina Donà, Matthias Koschutnik, Christina Binder, Christian Nitsche, Kseniya Halavina, Dietrich Beitzke, Christian Loewe, Philipp Bartko, Elisabeth Waldmann, Julia Mascherbauer, Christian Hengstenberg, Andreas Kammerlander

{"title":"Association of epicardial adipose tissue on magnetic resonance imaging with cardiovascular outcomes: Quality over quantity?","authors":"Franz Duca, Katharina Mascherbauer, Carolina Donà, Matthias Koschutnik, Christina Binder, Christian Nitsche, Kseniya Halavina, Dietrich Beitzke, Christian Loewe, Philipp Bartko, Elisabeth Waldmann, Julia Mascherbauer, Christian Hengstenberg, Andreas Kammerlander","doi":"10.1002/oby.24105","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>Epicardial adipose tissue (EAT) quantity is associated with poor cardiovascular outcomes. However, the quality of EAT may be of incremental prognostic value. Cardiac magnetic resonance (CMR) is the gold standard for tissue characterization but has never been applied for EAT quality assessment. We aimed to investigate EAT quality measured on CMR T1 mapping as a predictor of poor outcomes in an all-comer cohort.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>We investigated the association of EAT area and EAT T1 times (EAT-T1) with a composite endpoint of nonfatal myocardial infarction, heart failure hospitalization, and all-cause death.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>A total of 966 participants were included (47.2% female; mean age: 58.4 years) in this prospective observational CMR registry. Mean EAT area and EAT-T1 were 7.3 cm<sup>2</sup> and 268 ms, respectively. On linear regression, EAT-T1 was not associated with markers of obesity, dyslipidemia, or comorbidities such as diabetes (<i>p</i> > 0.05 for all). During a follow-up of 57.7 months, a total of 280 (29.0%) events occurred. EAT-T1 was independently associated (adjusted hazard ratio per SD: 1.202; 95% CI: 1.022–1.413; <i>p</i> = 0.026) with the composite endpoint when adjusted for established clinical risk.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>EAT quality (as assessed via CMR T1 times), but not EAT quantity, is independently associated with a composite endpoint of nonfatal myocardial infarction, heart failure hospitalization, and all-cause death.</p>\n \n <div>\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure>\n </div>\n </section>\n </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"32 9","pages":"1670-1679"},"PeriodicalIF":4.2000,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24105","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Obesity","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/oby.24105","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

Epicardial adipose tissue (EAT) quantity is associated with poor cardiovascular outcomes. However, the quality of EAT may be of incremental prognostic value. Cardiac magnetic resonance (CMR) is the gold standard for tissue characterization but has never been applied for EAT quality assessment. We aimed to investigate EAT quality measured on CMR T1 mapping as a predictor of poor outcomes in an all-comer cohort.

Methods

We investigated the association of EAT area and EAT T1 times (EAT-T1) with a composite endpoint of nonfatal myocardial infarction, heart failure hospitalization, and all-cause death.

Results

A total of 966 participants were included (47.2% female; mean age: 58.4 years) in this prospective observational CMR registry. Mean EAT area and EAT-T1 were 7.3 cm² and 268 ms, respectively. On linear regression, EAT-T1 was not associated with markers of obesity, dyslipidemia, or comorbidities such as diabetes (p > 0.05 for all). During a follow-up of 57.7 months, a total of 280 (29.0%) events occurred. EAT-T1 was independently associated (adjusted hazard ratio per SD: 1.202; 95% CI: 1.022–1.413; p = 0.026) with the composite endpoint when adjusted for established clinical risk.

Conclusions

EAT quality (as assessed via CMR T1 times), but not EAT quantity, is independently associated with a composite endpoint of nonfatal myocardial infarction, heart failure hospitalization, and all-cause death.

Abstract Image

查看原文本刊更多论文

磁共振成像中心外膜脂肪组织与心血管预后的关系：质量重于数量？

目的：心外膜脂肪组织（EAT心外膜脂肪组织（EAT）的数量与心血管不良预后有关。然而，心外膜脂肪组织的质量可能会增加预后价值。心脏磁共振（CMR）是组织特征描述的黄金标准，但从未用于 EAT 质量评估。我们的目的是研究在 CMR T1 图谱上测量的 EAT 质量是否可以预测所有患者的不良预后：我们研究了 EAT 面积和 EAT T1 时间（EAT-T1）与非致死性心肌梗死、心力衰竭住院和全因死亡等复合终点的关系：共有 966 名参与者（47.2% 为女性；平均年龄：58.4 岁）参与了这项前瞻性 CMR 观察登记。平均 EAT 面积和 EAT-T1 分别为 7.3 平方厘米和 268 毫秒。线性回归结果显示，EAT-T1 与肥胖、血脂异常或糖尿病等合并症的指标无关（所有指标的 p > 0.05）。在57.7个月的随访期间，共发生了280起（29.0%）事件。在对已确定的临床风险进行调整后，EAT-T1与综合终点独立相关（调整后的每标度危险比：1.202；95% CI：1.022-1.413；P = 0.026）：结论：EAT质量（通过CMR T1时间评估）而非EAT数量与非致死性心肌梗死、心力衰竭住院和全因死亡的复合终点有独立关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Obesity 医学-内分泌学与代谢

CiteScore

11.70

自引率

1.40%

发文量

261

审稿时长

2-4 weeks

期刊介绍： Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.