Total and Regional Fat-To-Muscle Mass Ratio in Relation to All-Cause and Cause-Specific Mortality in Men and Women.

IF 5 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Minzhi Xu, Yanhong Gong, Xiaoxv Yin
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引用次数: 0

Abstract

Context: Fat-to-muscle mass ratio (FMR) has been considered a potentially useful indicator for assessing disease risk. However, the association between FMR and risk of death remains inconclusive.

Objective: This work aimed to investigate the associations of FMR (the whole body, trunk, legs, and arms) with all-cause and cause-specific mortality by sex.

Methods: A total of 337 951 participants from the UK Biobank were included. Fat mass and muscle mass were estimated using a bioelectrical impedance assessment device. Cox proportional-hazard regression was applied to explore the associations.

Results: During a median follow-up of 12.58 years, we recorded 22 391 (6.62%) deaths, of which 4427 were from cardiovascular disease, 11 740 from cancer, and 1458 from respiratory disease. We observed associations of different shapes (U-shaped for whole body and trunk, L-shaped for legs, and J-shaped for arms) between FMR and all-cause mortality (P for nonlinearity <.001). Compared with the lowest quintile of whole body and trunk FMR, the all-cause mortality risk was reduced by 12% to 14% and 7% to 15% in men and women in quintiles 2 to 4, respectively. The hazard ratio (HR) associated with arm FMR in men and leg FMR in men and women (quintile 5 vs 1) were 1.14 (95% CI, 1.05-1.23), 0.76 (0.71-0.82), and 0.78 (0.70-0.88) for all-cause mortality, respectively. The associations between FMR and cause-specific mortality were mostly similar to those for all-cause mortality.

Conclusion: Our study revealed statistically significant associations of total and regional FMR with mortality, providing new evidence that FMR may be a potentially useful indicator for assessing mortality risk.

男性和女性的总质量和区域脂肪肌肉质量比与全因和特定原因死亡率的关系。
背景:脂肪与肌肉质量比(FMR)一直被认为是评估疾病风险的潜在有用指标。然而,脂肪和肌肉质量比与死亡风险之间的关系仍无定论:调查全身、躯干、腿部和手臂的脂肪和肌肉质量比与全因死亡率和特定原因死亡率之间的关系:方法:共纳入英国生物库中的 337951 名参与者。使用生物电阻抗评估装置估算脂肪量和肌肉量。结果:在中位随访 12.5 年的时间里,脂肪量和肌肉量的相关系数分别为 0.9 和 0.9:在 12.58 年的中位随访期间,我们记录了 22391 例(6.62%)死亡病例,其中 4427 例死于心血管疾病,11740 例死于癌症,1458 例死于呼吸系统疾病。我们观察到 FMR 与全因死亡率之间存在不同形状的关联(全身和躯干为 U 型,腿部为 L 型,手臂为 J 型)(P 为非线性结论):我们的研究揭示了总的和区域的血液透析比率与死亡率之间的重要关联,为血液透析比率可能成为评估死亡风险的有用指标提供了新的证据。
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来源期刊
Journal of Clinical Endocrinology & Metabolism
Journal of Clinical Endocrinology & Metabolism 医学-内分泌学与代谢
CiteScore
11.40
自引率
5.20%
发文量
673
审稿时长
1 months
期刊介绍: The Journal of Clinical Endocrinology & Metabolism is the world"s leading peer-reviewed journal for endocrine clinical research and cutting edge clinical practice reviews. Each issue provides the latest in-depth coverage of new developments enhancing our understanding, diagnosis and treatment of endocrine and metabolic disorders. Regular features of special interest to endocrine consultants include clinical trials, clinical reviews, clinical practice guidelines, case seminars, and controversies in clinical endocrinology, as well as original reports of the most important advances in patient-oriented endocrine and metabolic research. According to the latest Thomson Reuters Journal Citation Report, JCE&M articles were cited 64,185 times in 2008.
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