Overweight and Obesity in People Living With Type 1 Diabetes: A Cross-Sectional Analysis of the BETTER Registry

IF 4.6 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes/Metabolism Research and Reviews Pub Date : 2024-08-28 DOI:10.1002/dmrr.3837

Marie-Laure Lalanne-Mistrih, Anne Bonhoure, Virginie Messier, Valérie Boudreau, Maha Lebbar, Meryem K. Talbo, Cathy J. Sun, Aude Bandini, Laurence Secours, Virginie Calderon, Caroline Grou, Benoit Tressières, Anne-Sophie Brazeau, Rémi Rabasa-Lhoret

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Abstract

Aims

The prevalence and associations of overweight and obesity in Canadian adult people living with type 1 diabetes (PWT1D) are poorly documented. In a cohort of PWT1D patients, this study assesses (i) overweight and obesity frequencies and associated PWT1D clinicodemographic characteristics, (ii) diabetes characteristics, and (iii) the use of noninsulin adjunctive agents.

Materials and Methods

Cross-sectional analysis of self-reported data from the BETTER registry: 1091 adult PWT1D (aged 44.4 ± 15.0 years; 32% HbA1c<7% [53 mmol/mol]) classified by BMI classes: underweight combined with normal weight, overweight, or obesity. Bivariate analyses were used to identify associations between BMI classes, diabetes characteristics, complications, and treatments.

Results

Overweight and obesity affected 34.6% and 19.8% of participants. Compared to underweight + normal weight, PWT1D with overweight/obesity was associated with male sex, higher age, lower education level, longer diabetes duration, and higher total insulin doses and use of cardiorenal therapies (all p < 0.001). Compared to other PWT1D, those living with obesity reported higher HbA1c (p < 0.05), less frequent hypoglycemia (p < 0.05), more cardiovascular diseases (p < 0.003), retinopathy, neuropathy, depression treatment as well as noninsulin adjunctive agent use (all p < 0.001). Logistic regression showed that living with overweight/obesity was associated with male sex, being treated for cardiorenal therapies, depression, diabetes duration, and total daily insulin doses.

Conclusions

Overweight or obesity affects over half of adult PWT1D in the Canadian BETTER registry and is associated with higher HbA1c levels, higher total daily insulin doses, more chronic diabetes complications and noninsulin adjunctive agent use, a worse cardiometabolic profile, and lower hypoglycemia frequency.

Abstract Image

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1 型糖尿病患者的超重和肥胖：BETTER 登记的横断面分析。

目的：有关加拿大成年 1 型糖尿病患者（PWT1D）超重和肥胖的发生率及其相关性的资料很少。本研究在一组PWT1D患者中评估了(i)超重和肥胖频率及相关的PWT1D临床人口学特征，(ii)糖尿病特征，以及(iii)非胰岛素辅助药物的使用情况：对来自 BETTER 登记处的自我报告数据进行横断面分析：1091 名成年 PWT1D（年龄为 44.4 ± 15.0 岁；HbA1c 为 32%）：超重和肥胖分别影响 34.6% 和 19.8% 的参与者。与体重不足+体重正常的患者相比，超重/肥胖的PWT1D患者与男性性别、高年龄、低教育水平、糖尿病病程长、胰岛素总剂量高以及使用心肾治疗有关（所有P 均为0）：在加拿大 BETTER 登记中，超重或肥胖影响了一半以上的成年 PWT1D，并与较高的 HbA1c 水平、较高的每日胰岛素总剂量、较多的慢性糖尿病并发症和非胰岛素辅助药物的使用、较差的心脏代谢状况以及较低的低血糖频率有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes/Metabolism Research and Reviews 医学-内分泌学与代谢

CiteScore

17.20

自引率

2.50%

发文量

审稿时长

4-8 weeks

期刊介绍： Diabetes/Metabolism Research and Reviews is a premier endocrinology and metabolism journal esteemed by clinicians and researchers alike. Encompassing a wide spectrum of topics including diabetes, endocrinology, metabolism, and obesity, the journal eagerly accepts submissions ranging from clinical studies to basic and translational research, as well as reviews exploring historical progress, controversial issues, and prominent opinions in the field. Join us in advancing knowledge and understanding in the realm of diabetes and metabolism.