[Effect of Collagen Peptides on Function of Mouse T Lymphocytes under Simulated Microgravity].

Q4 Medicine

中国实验血液学杂志 Pub Date : 2024-08-01 DOI:10.19746/j.cnki.issn.1009-2137.2024.04.043

Shao-Yan Si, Ya-Ya Qin, Ying-Ying Wu, Xiao-Yu Ma, Ying Shang, Shu-Jun Song, Yan-Chuan Guo

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引用次数: 0

Abstract

Objective: To understand the effect of collagen peptides on the function of mouse lymphocytes under simulated microgravity.

Methods: The splenocytes of mice were isolated, and the rotary cell culture system was used to simulate the microgravity. The T lymphocytes were stimulated with mitotic agents, concanavalin A (ConA), and the cells were treated with different concentrations of collagen peptides. The proliferation of lymphocytes and the levels of cytokines in the supernatant were detected.

Results: Simulated microgravity could inhibit the proliferation of spleen T lymphocytes and decrease the level of cytokines in the supernatant. Collagen peptides could promote the lymphocyte proliferation and cytokine production in cells cultured under simulated microgravity.

Conclusion: Collagen peptides may attenuate the inhibitory effect of simulated microgravity on T lymphocytes by regulating the cell proliferation and the secretion of cytokines.

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[胶原蛋白肽对模拟微重力环境下小鼠 T 淋巴细胞功能的影响］

目的：了解胶原蛋白肽在模拟微重力环境下对小鼠淋巴细胞功能的影响：了解胶原蛋白肽在模拟微重力条件下对小鼠淋巴细胞功能的影响：方法：分离小鼠脾脏细胞，使用旋转细胞培养系统模拟微重力环境。方法：分离小鼠脾脏细胞，使用旋转细胞培养系统模拟微重力环境，用有丝分裂剂、康卡那华林 A（ConA）刺激 T 淋巴细胞，并用不同浓度的胶原蛋白肽处理细胞。检测淋巴细胞的增殖情况和上清液中细胞因子的水平：结果：模拟微重力能抑制脾脏 T 淋巴细胞的增殖，降低上清液中细胞因子的水平。结果：模拟微重力能抑制脾脏 T 淋巴细胞的增殖，降低上清液中细胞因子的水平；胶原蛋白肽能促进模拟微重力培养细胞中淋巴细胞的增殖和细胞因子的产生：结论：胶原蛋白肽可通过调节细胞增殖和细胞因子分泌，减轻模拟微重力对T淋巴细胞的抑制作用。

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来源期刊

中国实验血液学杂志 Medicine-Medicine (all)

CiteScore

0.40

自引率

0.00%

发文量

7331

期刊介绍：