Preoperative Symptom Duration and the Effect on Clinical Outcomes and PROMIS-PF in Patients Undergoing Lumbar Fusion Surgery.

IF 2.6 2区 医学 Q2 CLINICAL NEUROLOGY
Spine Pub Date : 2025-07-01 Epub Date: 2024-08-28 DOI:10.1097/BRS.0000000000005134
Andrea H Johnson, Jane C Brennan, Parimal Rana, Sarah Hall, Justin J Turcotte, Chad Patton
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Abstract

Study design: Retrospective review.

Objective: The purpose of this study is to examine the effect of preoperative symptom duration on postoperative clinical outcomes for patients undergoing lumbar fusion surgery.

Summary of background data: Lumbar fusion surgery can be significantly beneficial for lumbar spondylolisthesis and spinal stenosis. Surgical treatment is typically preceded by some amount of nonoperative intervention and there is no consensus on the optimal timing between symptom onset and surgical intervention.

Materials and methods: A retrospective review of 144 patients undergoing a one-level to three-level lumbar fusion from June 2020 to December 2023 was performed. Demographics, preoperative symptom onset, primary diagnosis, and surgical procedure were compared between patients with less than or greater than two years of symptoms. Postoperative outcomes and PROMIS-PF were compared between groups. Univariate and multivariate analyses were performed.

Results: Fifty-two (36.1%) had symptoms for two years or longer while 92 (63.9%) had symptoms for less than two years. There was no difference in demographics, procedure type, primary diagnosis, or preoperative symptoms between those who had symptoms for greater than or less than two years. Those who had symptoms for 2+ years had a significantly lower change in PF (4.7±7.1 vs. 7.7±9.0; P =0.029) and lower rate of MCID achievement (44.2% vs. 65.2%; P =0.023). There was no difference in outcomes by symptom duration. On multivariate analysis those with symptoms of two years or more were 2.4 times less likely to achieve an MCID (OR: 0.42, 95% CI: 0.19-0.92; P =0.031).

Conclusion: Patients undergoing lumbar fusion with greater than two years of symptoms before surgery have a smaller increase in PROMIS-PF and are less likely to achieve MCID on PROMIS-PF. Further study is needed to determine the optimal timing for lumbar fusion surgery following symptom onset.

腰椎融合手术患者术前症状持续时间及其对临床结果和 PROMIS-PF 的影响
研究设计回顾性研究:本研究旨在探讨腰椎融合手术患者术前症状持续时间对术后临床结果的影响:腰椎融合手术对腰椎滑脱症和椎管狭窄症有显著疗效。手术治疗前通常会进行一定程度的非手术干预,而症状出现与手术干预之间的最佳时机尚未达成共识:对 2020 年 6 月至 2023 年 12 月期间接受 1-3 级腰椎融合术的 144 名患者进行了回顾性研究。比较了症状出现时间少于或超过 2 年的患者的人口统计学特征、术前症状出现情况、主要诊断和手术方法。对各组患者的术后效果和 PROMIS-PF 进行了比较。进行了单变量和多变量分析:52例(36.1%)患者的症状持续了2年或更长时间,而92例(63.9%)患者的症状持续时间不足2年。在人口统计学、手术类型、主要诊断或术前症状方面,症状持续时间超过或少于 2 年的患者之间没有差异。症状持续 2 年以上者的 PF 变化显著较低(4.7±7.1 vs. 7.7±9.0;P=0.029),MCID 达标率也较低(44.2% vs. 65.2%;P=0.023)。症状持续时间不同,结果也不同。多变量分析显示,症状持续2年或2年以上的患者获得MCID的几率要低2.4倍(OR:0.42,95% CI:0.19至0.92;P=0.031):结论:接受腰椎融合术的患者在术前出现症状超过2年,其PROMIS-PF的增幅较小,且PROMIS-PF达到MCID的可能性较低。要确定症状出现后进行腰椎融合手术的最佳时机,还需要进一步研究。
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来源期刊
Spine
Spine 医学-临床神经学
CiteScore
5.90
自引率
6.70%
发文量
361
审稿时长
6.0 months
期刊介绍: Lippincott Williams & Wilkins is a leading international publisher of professional health information for physicians, nurses, specialized clinicians and students. For a complete listing of titles currently published by Lippincott Williams & Wilkins and detailed information about print, online, and other offerings, please visit the LWW Online Store. Recognized internationally as the leading journal in its field, Spine is an international, peer-reviewed, bi-weekly periodical that considers for publication original articles in the field of Spine. It is the leading subspecialty journal for the treatment of spinal disorders. Only original papers are considered for publication with the understanding that they are contributed solely to Spine. The Journal does not publish articles reporting material that has been reported at length elsewhere.
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