Uric acid and risk of gestational diabetes mellitus: an observational study and mendelian randomization analysis.

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Reproductive Biology and Endocrinology Pub Date : 2024-08-27 DOI:10.1186/s12958-024-01278-8

Nuerbiya Xilifu, Rui Zhang, Yongling Dai, Miyeshaer Maimaiti, Zhangyan Li, Ju Yang, Shufei Zang, Jun Liu

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Abstract

Objective: Our aim was to explore the relationship between serum uric acid (UA) levels in early pregnancy and the development of gestational diabetes mellitus (GDM), and to further explore whether there is a causal relationship.

Methods: 684 pregnant women with GDM and 1162 pregnant women without GDM participated in this study. 311 pregnant women with GDM and 311 matched controls were enrolled in a 1:1 case-control study. We used conditional logistic regression to explore the relationship between UA levels and the risk of developing GDM. The causal relationship between the two was examined by two-sample Mendelian randomization (MR) analysis.

Results: In the 1:1 matched population, the odds ratio (OR) of developing GDM compared with the extreme tertiles of UA levels was 1.967 (95% confidence interval [CI]: 1.475-2.625; P < 0.001). Restricted cubic spline analyses showed a linear relationship between UA and GDM when UA exceeded 222 µmol/L. GDM and UA levels maintained a statistically significant positive correlation in different stratified regression analyses (P < 0.001). However, no evidence of a causal relationship between uric acid and GDM was found by MR analyses with an OR of 1.06 (95% CI: 0.91-1.25) per unit increase in UA.

Conclusion: There is a positive correlation between UA levels in early pregnancy and the subsequent risk of developing GDM. However, no genetic evidence was found to support a cause-effect relationship between UA and GDM.

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尿酸与妊娠糖尿病的风险：一项观察性研究和孟德尔随机分析。

研究目的我们的目的是探讨妊娠早期血清尿酸（UA）水平与妊娠糖尿病（GDM）发生之间的关系，并进一步探讨两者之间是否存在因果关系。311名患有GDM的孕妇和311名匹配的对照组参加了1:1病例对照研究。我们采用条件逻辑回归法探讨了 UA 水平与 GDM 发病风险之间的关系。二者之间的因果关系通过双样本孟德尔随机分析（MR）进行了检验：结果：在 1:1 匹配的人群中，与 UA 水平的极端三分位数相比，罹患 GDM 的几率比（OR）为 1.967（95% 置信区间 [CI]：1.475-2.625）：P 结论：孕早期尿酸水平与随后罹患 GDM 的风险呈正相关。然而，没有发现遗传学证据支持 UA 与 GDM 之间的因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reproductive Biology and Endocrinology 医学-内分泌学与代谢

CiteScore

7.90

自引率

2.30%

发文量

161

审稿时长

4-8 weeks

期刊介绍： Reproductive Biology and Endocrinology publishes and disseminates high-quality results from excellent research in the reproductive sciences. The journal publishes on topics covering gametogenesis, fertilization, early embryonic development, embryo-uterus interaction, reproductive development, pregnancy, uterine biology, endocrinology of reproduction, control of reproduction, reproductive immunology, neuroendocrinology, and veterinary and human reproductive medicine, including all vertebrate species.