Clinical characteristics and therapeutic effect of myasthenia gravis coexisting with thyroid eye disease.

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY

Neurological Sciences Pub Date : 2024-12-01 Epub Date: 2024-08-28 DOI:10.1007/s10072-024-07728-w

Yin Chen, Shiyin Li, Jiaxin Chen, Huiyu Feng

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Abstract

Introduction: Here, we describe the clinical characteristics and therapeutic effects of myasthenia gravis (MG) coexisting with thyroid eye disease (TED).

Methods: We collated clinical data from MG patients in our hospital between 2012 and 2022 and analyzed the clinical characteristics of MG patients with hyperthyroidism, MG patients with TED and ocular myasthenia gravis (OMG) patients with TED.

Results: We recruited 62 MG patients with hyperthyroidism, including 13 MG patients with TED and 10 OMG patients with TED. There were 70 MG patients without hyperthyroidism; 29 of these were OMG. Compared with patients without hyperthyroidism, patients with hyperthyroidism had an earlier age at onset and milder clinical symptoms (P < 0.05). The incidence of thymus hyperplasia in patients with hyperthyroidism and TED was significantly lower than that in patients without TED (38.5% vs. 69.4%, P < 0.05); these patients also had a significantly lower antibody titer for the acetylcholine receptor [0.72 (0.27, 14.93) nmol/L vs. 2.38 (0.28, 49.51) nmol/L, P < 0.05]. Diplopia was significantly more frequent in OMG patients with TED than in patients with OMG (84.6% vs. 44.8%, P < 0.05), and the rate of diplopia in OMG patients with TED was significantly higher after treatment with bromostigmine and glucocorticoid (69.2% vs. 3.4%, P < 0.05).

Conclusions: MG patients with TED had a significantly lower incidence of thymus hyperplasia and a lower antibody titer for the acetylcholine receptor. Patients with OMG and TED are more likely to develop diplopia; it is very difficult to treat diplopia in these patients.

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合并甲状腺眼病的重症肌无力的临床特征和治疗效果。

简介方法：整理我院2012年至2022年MG患者的临床资料，分析MG合并甲亢、MG合并TED和眼肌型重症肌无力的临床特点及治疗效果：我们整理了我院2012年至2022年间MG患者的临床资料，分析了MG患者合并甲亢、MG患者合并TED以及眼肌型重症肌无力（OMG）患者合并TED的临床特征：我们招募了62名甲亢MG患者，其中包括13名TED MG患者和10名TED OMG患者。无甲亢的 MG 患者有 70 人，其中 29 人为 OMG 患者。与未患甲亢的患者相比，甲亢患者的发病年龄较早，临床症状较轻（P 结论：甲亢患者的临床症状较轻，而未患甲亢的患者的临床症状较重）：患有 TED 的 MG 患者胸腺增生发生率明显较低，乙酰胆碱受体抗体滴度也较低。OMG 和 TED 患者更容易出现复视；治疗这些患者的复视非常困难。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurological Sciences 医学-临床神经学

CiteScore

6.10

自引率

3.00%

发文量

743

审稿时长

4 months

期刊介绍： Neurological Sciences is intended to provide a medium for the communication of results and ideas in the field of neuroscience. The journal welcomes contributions in both the basic and clinical aspects of the neurosciences. The official language of the journal is English. Reports are published in the form of original articles, short communications, editorials, reviews and letters to the editor. Original articles present the results of experimental or clinical studies in the neurosciences, while short communications are succinct reports permitting the rapid publication of novel results. Original contributions may be submitted for the special sections History of Neurology, Health Care and Neurological Digressions - a forum for cultural topics related to the neurosciences. The journal also publishes correspondence book reviews, meeting reports and announcements.