Lin Li, Yusuke Matsui, Mary K Prahl, Arianna G Cassidy, Yarden Golan, Unurzul Jigmeddagva, Nida Ozarslan, Christine Y Lin, Sirirak Buarpung, Veronica J Gonzalez, Megan A Chidboy, Emilia Basilio, Kara L Lynch, Dongli Song, Priya Jegatheesan, Daljeet S Rai, Balaji Govindaswami, Jordan Needens, Monica Rincon, Leslie Myatt, Taha Y Taha, Mauricio Montano, Melanie Ott, Warner C Greene, Stephanie L Gaw
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引用次数: 0
Abstract
Hybrid immunity against SARS-CoV-2 has not been well studied in pregnancy. We conducted a comprehensive analysis of neutralizing antibodies (nAb) and binding antibodies in pregnant individuals who received mRNA vaccination, natural infection, or both. A third vaccine dose augmented nAb levels compared to the two-dose regimen or natural infection alone; this effect was more pronounced in hybrid immunity. There was reduced anti-Omicron nAb, but the maternal-fetal transfer efficiency remained comparable to that of other variants. Vaccine-induced nAbs were transferred more efficiently than infection-induced nAbs. Anti-spike receptor binding domain (RBD) IgG was associated with nAb against wild-type (Wuhan-Hu-1) following breakthrough infection. Both vaccination and infection-induced anti-RBD IgA, which was more durable than anti-nucleocapsid IgA. IgA response was attenuated in pregnancy compared to non-pregnant controls. These data provide additional evidence of augmentation of humoral immune responses in hybrid immunity in pregnancy.
NPJ VaccinesImmunology and Microbiology-Immunology
CiteScore
11.90
自引率
4.30%
发文量
146
审稿时长
11 weeks
期刊介绍:
Online-only and open access, npj Vaccines is dedicated to highlighting the most important scientific advances in vaccine research and development.