Diagnostic value of soluble Interleukin-2 receptor in patients suffering neurosarcoidosis: A systematic review.

IF 2.6 Q2 CLINICAL NEUROLOGY
Journal of Central Nervous System Disease Pub Date : 2024-08-26 eCollection Date: 2024-01-01 DOI:10.1177/11795735241274186
Aditya Chanpura, Rajesh K Gupta, Shitiz K Sriwastava, Jan Rahmig
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引用次数: 0

Abstract

Background: Neurosarcoidosis is an inflammatory granulomatous disease. Up to 25% of occult sarcoidosis affecting the nervous system are only detected by autopsy. In addition, in recent years the suspicion arose that the soluble Interleukin-2 Receptor (sIL-2R) might be useful in differentiating between neurosarcoidosis and neurosarcoidosis-like diseases such as neurotuberculosis, multiple sclerosis, or cerebral lymphoma.

Objectives: Therefore, we aimed to systematically review randomized controlled trials (RCT), observational studies, and case-control studies evaluating sIL-2R levels in neurosarcoidosis patients.

Design: For this systematic review, a comprehensive literature search of electronic databases including EMBASE, The Web Of Science, The Cochrane Library, MEDLINE, and Google Scholar was conducted. The search was limited to the English language and publication date up to January 08th, 2024.

Data sources and methods: As part of the search strategy conducted, 6 articles met the inclusion criteria. Two independent reviewers extracted the relevant data from each article. In addition, 2 independent reviewers assessed the quality of each study using the Newcastle-Ottawa Scale (NOS).

Results: We included 6 studies comprising 98 patients suffering from neurosarcoidosis, 525 non-sarcoidosis patients, and 118 healthy controls. Included studies were published between 2010 and 2023. Cerebrospinal fluid (CSF) sIL-2R levels differed significantly between neurosarcoidosis patients and multiple sclerosis, vasculitis, and healthy controls whereas serum sIL-2R levels did not reveal sufficient discriminative power. sIL-2R index was able to discriminate neurosarcoidosis from neurotuberculosis, bacterial/viral meningitis, and healthy controls.

Conclusions: In this systematic review, we found indications that sIL-2R may be a useful biomarker for the diagnosis of neurosarcoidosis. To determine an additional diagnostic value of sIL-2R, large prospective studies are needed that not only examine absolute sIL-2R levels in serum or CSF but also the dynamic changes as well as the implications of renal function on sIL-2R levels.

可溶性白细胞介素-2 受体在神经肉芽肿病患者中的诊断价值:系统综述。
背景:神经肉芽肿病是一种炎症性肉芽肿疾病:神经肉芽肿病是一种炎症性肉芽肿疾病。在影响神经系统的隐匿性肉样瘤病中,高达 25% 的病例只能通过尸检才能发现。此外,近年来有人怀疑可溶性白细胞介素-2受体(sIL-2R)可能有助于区分神经肉芽肿病和神经肉芽肿病样疾病,如神经结核、多发性硬化或脑淋巴瘤:因此,我们旨在系统回顾评估神经肉芽肿病患者 sIL-2R 水平的随机对照试验 (RCT)、观察性研究和病例对照研究:为了进行此次系统性综述,我们对电子数据库进行了全面的文献检索,包括 EMBASE、The Web Of Science、The Cochrane Library、MEDLINE 和 Google Scholar。检索仅限于英语,发表日期截至 2024 年 1 月 8 日:作为搜索策略的一部分,有 6 篇文章符合纳入标准。两名独立审稿人从每篇文章中提取了相关数据。此外,两名独立审稿人还使用纽卡斯尔-渥太华量表(NOS)对每篇研究的质量进行了评估:我们纳入了 6 项研究,包括 98 名神经肉样瘤病患者、525 名非肉样瘤病患者和 118 名健康对照者。所纳入的研究发表于 2010 年至 2023 年之间。脑脊液(CSF)sIL-2R水平在神经肉芽肿病患者与多发性硬化症、血管炎和健康对照组之间存在显著差异,而血清sIL-2R水平没有显示出足够的鉴别力:在这篇系统综述中,我们发现有迹象表明 sIL-2R 可能是诊断神经肉芽肿病的有用生物标志物。为了确定 sIL-2R 的其他诊断价值,需要进行大规模的前瞻性研究,不仅要检测血清或脑脊液中 sIL-2R 的绝对水平,还要检测其动态变化以及肾功能对 sIL-2R 水平的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.90
自引率
0.00%
发文量
39
审稿时长
8 weeks
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