Hot Hearts on Bone Scintigraphy Are Not All Amyloidosis: Hyperoxaluria-Associated Cardiomyopathy.

IF 9.6 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Clinical Nuclear Medicine Pub Date : 2024-12-01 Epub Date: 2024-08-28 DOI:10.1097/RLU.0000000000005411

Ya-Wen Wang, Yan-Ting Xie, Xiao-Xin Sun

引用次数: 0

Abstract

Abstract: A 54-year-old woman with a history of end-stage renal disease was found to have infiltrative cardiomyopathy by echocardiography. 99m Tc-pyrophosphate ( 99m Tc-PYP) scintigraphy was positive with a remarkable myocardial uptake. Gene test found a mutation of AGXT , confirming a final diagnosis of primary hyperoxaluria. Radiotracer uptake was due to high myocardial oxalate deposition. This case illustrates false positivity of the 99m Tc-PYP scan caused by hyperoxaluria-associated cardiomyopathy, which raises awareness for other conditions apart from amyloid cardiomyopathy.

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骨闪烁成像上的 "热心 "并非都是淀粉样变性：高草酸尿症相关心肌病。

摘要：一名有终末期肾病病史的 54 岁妇女经超声心动图检查发现患有浸润性心肌病。99m锝-焦磷酸（99m锝-PYP）闪烁扫描呈阳性，心肌摄取显著。基因检测发现了 AGXT 突变，最终确诊为原发性高草酸尿症。放射性示踪剂摄取是由于心肌草酸盐沉积过高所致。本病例说明了高草酸血症相关心肌病导致的 99mTc-PYP 扫描假阳性，从而提高了人们对淀粉样变性心肌病以外的其他疾病的认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Nuclear Medicine 医学-核医学

CiteScore

2.90

自引率

31.10%

发文量

1113

审稿时长

2 months

期刊介绍： Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.