Akmal Zubair, Bushra Bibi, Faiza Habib, Arooba Sujan, Muhammad Ali
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引用次数: 0
Abstract
The greatest obstacle for scientists is to develop an effective HIV vaccine. An effective vaccine represents the last hope for halting the unstoppable global spread of HIV and its catastrophic clinical consequences. Creating this vaccine has been challenging due to the virus’s extensive genetic variability and the unique role of cytotoxic T lymphocytes (CTL) in containing it. Innovative methods to stimulate CTL have demonstrated significant therapeutic advantages in nonhuman primate model systems, unlike traditional vaccination techniques that are not expected to provide safe and efficient protection against HIV. Human clinical trials are currently evaluating these vaccination strategies, which involve plasmid DNA and live recombinant vectors. This review article covers the existing vaccines and ongoing trial vaccines. It also explores the different approaches used in developing HIV vaccines, including their molecular mechanisms, target site effectiveness, and potential side effects.
科学家们面临的最大障碍是研制出有效的艾滋病疫苗。有效的疫苗是阻止 HIV 在全球范围内不可阻挡的传播及其灾难性临床后果的最后希望。由于病毒具有广泛的基因变异性，而且细胞毒性 T 淋巴细胞 (CTL) 在抑制病毒方面发挥着独特的作用，因此研制这种疫苗一直充满挑战。在非人灵长类动物模型系统中，刺激 CTL 的创新方法已显示出显著的治疗优势，这与传统的疫苗接种技术不同，传统的疫苗接种技术无法提供安全有效的艾滋病病毒防护。人类临床试验目前正在评估这些疫苗接种策略，其中涉及质粒 DNA 和活重组载体。这篇综述文章介绍了现有的疫苗和正在进行的试验疫苗。文章还探讨了开发 HIV 疫苗的不同方法，包括其分子机制、靶点有效性和潜在副作用。
期刊介绍：
Functional & Integrative Genomics is devoted to large-scale studies of genomes and their functions, including systems analyses of biological processes. The journal will provide the research community an integrated platform where researchers can share, review and discuss their findings on important biological questions that will ultimately enable us to answer the fundamental question: How do genomes work?
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