Fabrication of micro-porous polymeric coating with dynamic drug-eluting property on plastic biliary stent for antiproliferative treatment

IF 4.7 3区材料科学 Q2 CHEMISTRY, PHYSICAL

Colloid and Interface Science Communications Pub Date : 2024-08-27 DOI:10.1016/j.colcom.2024.100801

{"title":"Fabrication of micro-porous polymeric coating with dynamic drug-eluting property on plastic biliary stent for antiproliferative treatment","authors":"","doi":"10.1016/j.colcom.2024.100801","DOIUrl":null,"url":null,"abstract":"<div><p>The current study aims to construct additional drug-eluting carrier for commercially available biliary stent, providing a practical strategy for the cost-efficient treatment of benign biliary stricture. Specifically, the commercially available biliary stent was endowed with porous polylactic acid coating <em>via in-situ</em> pore-formation induced by solvent treatment. The drug-eluting stent with fibroblast inhibition effect was successfully established by efficiently loading the antiproliferative drug of triamcinolone acetonide into the porous coating. The drug release behavior could be dynamically controlled by adjusting the pore morphology of the porous coating. The <em>in-vitro</em> coating degradation and the fibroblast inhibition effect of the drug-eluting stents were further evaluated to prove the effectiveness of the fabricated porous coating as an antiproliferative drug carrier.</p></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":null,"pages":null},"PeriodicalIF":4.7000,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2215038224000360/pdfft?md5=86a5a25e7dac12c0d628a8181babf102&pid=1-s2.0-S2215038224000360-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Colloid and Interface Science Communications","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2215038224000360","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}

引用次数: 0

Abstract

The current study aims to construct additional drug-eluting carrier for commercially available biliary stent, providing a practical strategy for the cost-efficient treatment of benign biliary stricture. Specifically, the commercially available biliary stent was endowed with porous polylactic acid coating via in-situ pore-formation induced by solvent treatment. The drug-eluting stent with fibroblast inhibition effect was successfully established by efficiently loading the antiproliferative drug of triamcinolone acetonide into the porous coating. The drug release behavior could be dynamically controlled by adjusting the pore morphology of the porous coating. The in-vitro coating degradation and the fibroblast inhibition effect of the drug-eluting stents were further evaluated to prove the effectiveness of the fabricated porous coating as an antiproliferative drug carrier.

Abstract Image

查看原文本刊更多论文

在塑料胆道支架上制作具有动态药物洗脱特性的微孔聚合物涂层，用于抗增生治疗

本研究旨在为市售胆道支架构建额外的药物洗脱载体，为经济有效地治疗良性胆道狭窄提供一种实用策略。具体来说，通过溶剂处理在原位形成孔隙，为市售胆道支架添加多孔聚乳酸涂层。通过在多孔涂层中有效负载抗增殖药物曲安奈德，成功制备出了具有成纤维细胞抑制作用的药物洗脱支架。通过调节多孔涂层的孔隙形态，可以动态控制药物的释放行为。实验还进一步评估了药物洗脱支架的体外涂层降解和成纤维细胞抑制效果，以证明所制备的多孔涂层作为抗增殖药物载体的有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Colloid and Interface Science Communications Materials Science-Materials Chemistry

CiteScore

9.40

自引率

6.70%

发文量

125

审稿时长

43 days

期刊介绍： Colloid and Interface Science Communications provides a forum for the highest visibility and rapid publication of short initial reports on new fundamental concepts, research findings, and topical applications at the forefront of the increasingly interdisciplinary area of colloid and interface science.