Impact of alcohol dehydrogenase 3 (ADH3 or ADH1C) genetic variation on head and neck cancer susceptibility: A systematic review, meta-analysis, functional analysis, and trial sequential analysis

IF 2.9 4区医学 Q2 PATHOLOGY

Pathology, research and practice Pub Date : 2024-08-27 DOI:10.1016/j.prp.2024.155561

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引用次数: 0

Abstract

Objectives

Alcohol drinking is a major risk factor for head and neck cancer (HNC), and this risk may be modified by alcohol dehydrogenase (ADH) genes. The first systematic review and meta-analysis was designed with more studies and added trial sequential analysis and functional analysis for a better understanding of the role of ADH3 polymorphism in HNC patients.

Methods

A search was performed across several databases, including PubMed/Medline, Web of Science, Scopus, and Cochrane Library, up to May 5, 2024, without any restrictions to find pertinent studies. The RevMan 5.3 software was used to calculate the effect sizes. These were expressed as the odds ratio (OR) with a 95 % confidence interval.

Results

Twenty-seven articles were included in the meta-analysis. The frequency of *1/*1, *1/*2, and *2/*2 genotypes in cases with HNC was 47.14 %, 41.06 %, and 11.80 %, respectively, and in controls was 50.56 %, 38.29 %, and 11.15 %, respectively. The pooled OR for the allelic model is 1.11 (p = 0.18), for the homozygous model is 0.95 (p = 0.64), for the heterozygous model is 0.99 (p = 0.90), for the dominant model is 1.11 (p = 0.14), and for the recessive model is 0.98 (p = 0.78). In the Asians, the three models showed an increased significant association. In the cancer subtype subgroup, a protective significant association was found in the pharyngeal cancer subtype.

Conclusions

The current analysis suggests that ADH3 polymorphism may not have a significant impact on the risk of HNC, but the polymorphism had an increased risk in Asians and a protective role in pharyngeal cancers.

查看原文本刊更多论文

酒精脱氢酶 3（ADH3 或 ADH1C）基因变异对头颈部癌症易感性的影响：系统综述、荟萃分析、功能分析和试验序列分析

目的饮酒是头颈癌（HNC）的主要风险因素，而酒精脱氢酶（ADH）基因可能会改变这一风险。为了更好地了解 ADH3 多态性在 HNC 患者中的作用，首次系统综述和荟萃分析设计了更多的研究，并增加了试验序列分析和功能分析。方法在多个数据库中进行检索，包括 PubMed/Medline、Web of Science、Scopus 和 Cochrane Library，检索时间截至 2024 年 5 月 5 日，没有任何限制，以找到相关研究。使用 RevMan 5.3 软件计算效应大小。结果共有 27 篇文章被纳入荟萃分析。HNC病例中*1/*1、*1/*2和*2/*2基因型的频率分别为47.14%、41.06%和11.80%，而对照组中*1/*1、*1/*2和*2/*2基因型的频率分别为50.56%、38.29%和11.15%。等位基因模型的集合 OR 为 1.11（P = 0.18），同源模型为 0.95（P = 0.64），异源模型为 0.99（P = 0.90），显性模型为 1.11（P = 0.14），隐性模型为 0.98（P = 0.78）。在亚洲人中，三个模型都显示出更显著的关联性。结论目前的分析表明，ADH3 多态性可能对 HNC 风险没有显著影响，但该多态性在亚洲人中的风险增加，在咽癌中具有保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathology, research and practice 医学-病理学

CiteScore

5.00

自引率

3.60%

发文量

405

审稿时长

24 days

期刊介绍： Pathology, Research and Practice provides accessible coverage of the most recent developments across the entire field of pathology: Reviews focus on recent progress in pathology, while Comments look at interesting current problems and at hypotheses for future developments in pathology. Original Papers present novel findings on all aspects of general, anatomic and molecular pathology. Rapid Communications inform readers on preliminary findings that may be relevant for further studies and need to be communicated quickly. Teaching Cases look at new aspects or special diagnostic problems of diseases and at case reports relevant for the pathologist''s practice.