Recent Progress in Molecular Probes for Imaging of Acute Kidney Injury

Chemical & Biomedical Imaging Pub Date : 2024-05-01 DOI:10.1021/cbmi.4c0002410.1021/cbmi.4c00024

Muqadas Sitara, Wangning Zhang, Han Gao, Jiwei Li* and Jiangwei Tian*,

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Abstract

Acute kidney injury (AKI), a prevalent and complex clinical condition associated with elevated risks of morbidity and mortality, necessitates the meticulous detection and monitoring of kidney damage globally. Biomedicine has shown keen interest in molecular probes and detectors for AKI due to their sensitivity, rapidity, and cost-effectiveness. Bioimaging technologies play a significant role in identifying and quantifying AKI indicators, enhancing diagnostic approaches, and potentially refining clinical therapies for immediate injury control. Molecular probes serve as valuable tools for drug screening, uncovering renoprotective components, signaling pathways, and the nephrotoxic effects of drugs. This review comprehensively summarizes the latest advancements in molecular probes, emphasizing their exceptional efficacy in various characteristics, including renal cleanability, multichannel detection capability, near-infrared-II responsiveness, and reactivity toward reactive oxygen species. These probes offer enhanced benefits for assessing kidney damage and evaluating the therapeutic effects of medications while simultaneously reducing toxic effects. Additionally, the review delves into future potentials and challenges in this field, aiming to inspire the development and enhancement of molecular bioimaging for the early diagnosis and treatment of kidney diseases.

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急性肾损伤成像分子探针的最新进展

急性肾损伤（AKI）是一种普遍而复杂的临床病症，具有较高的发病率和死亡率风险，因此有必要在全球范围内对肾损伤进行细致的检测和监测。生物医学对 AKI 分子探针和检测器表现出浓厚的兴趣，因为它们灵敏、快速、成本效益高。生物成像技术在确定和量化 AKI 指标、增强诊断方法以及改进临床疗法以立即控制损伤方面发挥着重要作用。分子探针是药物筛选的重要工具，可发现肾保护成分、信号通路和药物的肾毒性作用。本综述全面总结了分子探针的最新进展，强调了它们在各种特性方面的卓越功效，包括肾脏清洁性、多通道检测能力、近红外 II 反应性和对活性氧的反应性。这些探针为评估肾脏损伤和药物治疗效果提供了更多益处，同时还降低了毒性效应。此外，这篇综述还深入探讨了这一领域未来的潜力和挑战，旨在激励分子生物成像技术的发展和提高，以用于肾脏疾病的早期诊断和治疗。

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来源期刊

Chemical & Biomedical Imaging 化学与生物成像-

CiteScore

1.00

自引率

0.00%

发文量

期刊介绍： Chemical & Biomedical Imaging is a peer-reviewed open access journal devoted to the publication of cutting-edge research papers on all aspects of chemical and biomedical imaging. This interdisciplinary field sits at the intersection of chemistry physics biology materials engineering and medicine. The journal aims to bring together researchers from across these disciplines to address cutting-edge challenges of fundamental research and applications.Topics of particular interest include but are not limited to:Imaging of processes and reactionsImaging of nanoscale microscale and mesoscale materialsImaging of biological interactions and interfacesSingle-molecule and cellular imagingWhole-organ and whole-body imagingMolecular imaging probes and contrast agentsBioluminescence chemiluminescence and electrochemiluminescence imagingNanophotonics and imagingChemical tools for new imaging modalitiesChemical and imaging techniques in diagnosis and therapyImaging-guided drug deliveryAI and machine learning assisted imaging