The Association between Residential Segregation and Access to Kidney Transplantation: Evidence from a Multistate Cohort Study.

IF 8.5 1区 医学 Q1 UROLOGY & NEPHROLOGY
Jasmine Berry, Aubriana Perez, Mengyu Di, Chengcheng Hu, Stephen O Pastan, Rachel E Patzer, Jessica L Harding
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引用次数: 0
居住地隔离与肾移植机会之间的关系--来自多州队列研究的证据》(The Association Between Residential Segregation and Access to Kidney Transplantation - Evidence from a Multi-State Cohort Study)。
背景:目前生活在受种族隔离历史影响的社区的人获得医疗保健的机会较少。对于寻求移植的终末期肾病(ESKD)患者来说,情况是否如此尚不清楚:我们从美国肾脏数据系统(USRDS)中识别了2015年1月至2019年12月期间在美国三个州(佐治亚州、北卡罗来纳州、南卡罗来纳州)开始接受肾脏替代治疗(KRT)的黑人或白人成人(n = 42,401; 18-80岁),并随访至2020年。住宅隔离采用种族极端集中指数(the racial Index of Concentration at the Extremmes)进行定义,并分为三等分(主要为黑人区、混合区或主要为白人区)。主要结果是开始 KRT 后 12 个月内的转诊情况(在开始 KRT 的患者中)和转诊后 6 个月内的评估情况(在所有转诊患者中),这些结果是通过将 USRDS 与早期移植途径登记处(Early-Steps to Transplant Access Registry)连接确定的。次要结果包括候选名单(在接受评估的患者中)以及活体或死体捐献移植(在候选名单上的患者中)。使用多变量 Cox 模型和稳健的三明治方差估计器评估了居住隔离与各项结果之间的关系:结果:在根据临床因素调整后的模型中,居住在以黑人为主或混血(与以白人为主相比)社区的人被转诊接受肾移植的可能性分别降低了 8%(调整后危险比(aHR)为 0.92 [0.88 - 0.96])和 5%(aHR:0.95 [0.91 - 0.99])、18%(aHR:0.在开始评估的患者中,分别有 18%(aHR: 0.82 [0.76 - 0.90])和 9%(aHR: 0.91 [0.84 - 0.98])的患者被列入等待名单的可能性较低;在被列入等待名单的患者中,分别有 54%(aHR: 0.46 [0.36 - 0.58])和 24%(aHR: 0.76 [0.63 - 0.93])的患者接受活体肾移植的可能性较低。其他移植步骤的相关性不显著:结论:生活在美国东南部历史上和目前被边缘化社区的 ESKD 患者在接受移植治疗的重要环节中机会较少。
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来源期刊
CiteScore
12.20
自引率
3.10%
发文量
514
审稿时长
3-6 weeks
期刊介绍: The Clinical Journal of the American Society of Nephrology strives to establish itself as the foremost authority in communicating and influencing advances in clinical nephrology by (1) swiftly and effectively disseminating pivotal developments in clinical and translational research in nephrology, encompassing innovations in research methods and care delivery; (2) providing context for these advances in relation to future research directions and patient care; and (3) becoming a key voice on issues with potential implications for the clinical practice of nephrology, particularly within the United States. Original manuscript topics cover a range of areas, including Acid/Base and Electrolyte Disorders, Acute Kidney Injury and ICU Nephrology, Chronic Kidney Disease, Clinical Nephrology, Cystic Kidney Disease, Diabetes and the Kidney, Genetics, Geriatric and Palliative Nephrology, Glomerular and Tubulointerstitial Diseases, Hypertension, Maintenance Dialysis, Mineral Metabolism, Nephrolithiasis, and Transplantation.
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