Disrupted Circadian Rhythms and Substance Use Disorders: A Narrative Review.

IF 2.1 Q3 CLINICAL NEUROLOGY
Pallavi Sharma, Randy J Nelson
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引用次数: 0

Abstract

Substance use disorder is a major global health concern, with a high prevalence among adolescents and young adults. The most common substances of abuse include alcohol, marijuana, cocaine, nicotine, and opiates. Evidence suggests that a mismatch between contemporary lifestyle and environmental demands leads to disrupted circadian rhythms that impair optimal physiological and behavioral function, which can increase the vulnerability to develop substance use disorder and related problems. The circadian system plays an important role in regulating the sleep-wake cycle and reward processing, both of which directly affect substance abuse. Distorted substance use can have a reciprocal effect on the circadian system by influencing circadian clock gene expression. Considering the detrimental health consequences and profound societal impact of substance use disorder, it is crucial to comprehend its complex association with circadian rhythms, which can pave the way for the generation of novel chronotherapeutic treatment approaches. In this narrative review, we have explored the potential contributions of disrupted circadian rhythms and sleep on use and relapse of different substances of abuse. The involvement of circadian clock genes with drug reward pathways is discussed, along with the potential research areas that can be explored to minimize disordered substance use by improving circadian hygiene.

昼夜节律紊乱与药物使用失调:叙述性综述。
药物滥用障碍是全球关注的一大健康问题,在青少年和年轻成年人中发病率很高。最常见的滥用药物包括酒精、大麻、可卡因、尼古丁和鸦片制剂。有证据表明,当代生活方式与环境需求不匹配会导致昼夜节律紊乱,从而损害最佳生理和行为功能,这可能会增加出现药物滥用障碍和相关问题的可能性。昼夜节律系统在调节睡眠-觉醒周期和奖赏处理方面发挥着重要作用,而这两者都会直接影响药物滥用。滥用药物会影响昼夜节律时钟基因的表达,从而对昼夜节律系统产生相互影响。考虑到药物滥用障碍对健康造成的有害后果和深远的社会影响,理解其与昼夜节律的复杂联系至关重要,这可以为产生新型的时间治疗方法铺平道路。在这篇叙述性综述中,我们探讨了昼夜节律紊乱和睡眠对不同药物滥用和复发的潜在影响。文中讨论了昼夜节律基因与药物奖赏途径的关系,以及通过改善昼夜节律卫生来尽量减少药物滥用的潜在研究领域。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clocks & Sleep
Clocks & Sleep Multiple-
CiteScore
4.40
自引率
0.00%
发文量
0
审稿时长
7 weeks
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