Poor sleep quality is associated with decreased regional brain glucose metabolism in healthy middle-aged adults

IF 4.7 2区医学 Q1 NEUROIMAGING

NeuroImage Pub Date : 2024-08-24 DOI:10.1016/j.neuroimage.2024.120814

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引用次数: 0

Abstract

Sleep disturbance is associated with the development of neurodegenerative disease. We aimed to address the effects of sleep quality on brain glucose metabolism measured by ¹⁸F-Fl uorodeoxyglucose (¹⁸F-FDG) positron emission tomography (PET) in healthy middle-aged adults. A total of 378 healthy men (mean age: 42.8±3.6 years) were included in this study. Participants underwent brain ¹⁸F-FDG PET and completed the Korean version of the Pittsburgh Sleep Quality Index (PSQI-K). Additionally, anthropometric measurements were obtained. PETs were spatially normalized to MNI space using PET templates from SPM5 with PMOD. The Automated Anatomical Labeling 2 atlas was used to define regions of interest (ROIs). The mean uptake of each ROI was scaled to the mean of the global cortical uptake of each individual and defined as the standardized uptake value ratio (SUVR). After the logarithmic transformation of the regional SUVR, the effects of the PSQI-K on the regional SUVR were investigated using Bayesian hierarchical modeling. Brain glucose metabolism of the posterior cingulate, precuneus, and thalamus showed a negative association with total PSQI-K scores in the Bayesian model ROI-based analysis. Voxel-based analysis using statistical parametric mapping revealed a negative association between the total PSQI-K scores and brain glucose metabolism of the precuneus, postcentral gyrus, posterior cingulate, and thalamus. Poor sleep quality is negatively associated with brain glucose metabolism in the precuneus, posterior cingulate, and thalamus. Therefore, the importance of sleep should not be overlooked, even in healthy middle-aged adults.

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睡眠质量差与健康中年人大脑区域葡萄糖代谢减少有关。

睡眠障碍与神经退行性疾病的发展有关。我们的目的是研究睡眠质量对健康中年人脑葡萄糖代谢的影响（18F-Fl uorodeoxyglucose (18F-FDG) positron emission tomography (PET)）。本研究共纳入了 378 名健康男性（平均年龄：42.8±3.6 岁）。参与者接受了脑18F-FDG正电子发射计算机断层扫描，并完成了韩国版匹兹堡睡眠质量指数（PSQI-K）。此外，还进行了人体测量。使用 SPM5 和 PMOD 的 PET 模板将 PET 空间归一化到 MNI 空间。自动解剖标记 2 图集用于定义感兴趣区（ROI）。每个 ROI 的平均摄取量与每个人的全球皮质摄取量的平均值进行缩放，并定义为标准化摄取值比（SUVR）。对区域 SUVR 进行对数转换后，使用贝叶斯层次模型研究 PSQI-K 对区域 SUVR 的影响。在基于贝叶斯模型的 ROI 分析中，后扣带回、楔前区和丘脑的脑糖代谢与 PSQI-K 总分呈负相关。基于体素的统计参数映射分析显示，PSQI-K 总分与楔前、中央后回、扣带回后和丘脑的脑糖代谢呈负相关。睡眠质量差与楔前、扣带回后和丘脑的脑糖代谢呈负相关。因此，即使是健康的中年人也不应忽视睡眠的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NeuroImage 医学-核医学

CiteScore

11.30

自引率

10.50%

发文量

809

审稿时长

63 days

期刊介绍： NeuroImage, a Journal of Brain Function provides a vehicle for communicating important advances in acquiring, analyzing, and modelling neuroimaging data and in applying these techniques to the study of structure-function and brain-behavior relationships. Though the emphasis is on the macroscopic level of human brain organization, meso-and microscopic neuroimaging across all species will be considered if informative for understanding the aforementioned relationships.