Exploring gastrointestinal manifestations in childhood onset systemic lupus erythematosus - Insights from a multicenter study.

IF 1.9 4区 医学 Q3 RHEUMATOLOGY
Lupus Pub Date : 2024-10-01 Epub Date: 2024-08-26 DOI:10.1177/09612033241279071
Hafize Emine Sönmez, Ezgi Deniz Batu, Rana İşgüder, Nihal Şahin, Emil Aliyev, Esma Aslan, Sümeyra Çoban, Vildan Güngörer, Şerife Gül Karadağ, Nihal Karaçayır, Hakan Kısaoğlu, Aydan Yekedüz Bülbül, Sevinç Garip, Yasin Karalı, Semra Ayduran, Selcan Demir, Ümmüşen Kaya Akça, Özge Başaran, Sezgin Şahin, Belde Kasap, Sara Sebnem Kilic, Rabia Miray Kışla Ekinci, Ayşenur Paç Kısaarslan, Mukaddes Kalyoncu, Sevcan Bakkaloğlu, Selçuk Yüksel, Nuray Aktay Ayaz, Banu Çelikel Acar, Betül Sözeri, Özgür Kasapçopur, Erbil Ünsal, Seza Özen
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引用次数: 0

Abstract

Objective: Systemic lupus erythematosus (SLE) constitutes an autoimmune disorder with potential involvement of the gastrointestinal system (GIS). Our objective was to assess the gastrointestinal (GI) manifestations in patients diagnosed with childhood onset SLE.

Methods: The study cohort consisted of 123 patients with childhood onset-SLE and GIS involvement from 16 referral departments of pediatric rheumatology. All participants met the Systemic Lupus International Collaborating Clinics criteria.

Results: Out of 123 patients, 78 (63.4%) exhibited GIS involvement at the initial SLE diagnosis, whereas the remaining 45 (36.6%) developed GI symptoms after a median duration of 12 (3-140) months. Eighty-two (66.7%) individuals experienced symptoms related to the GI tract, whereas the remaining patients received a diagnosis of GI involvement through laboratory assessments. The predominant initial GIS involvement symptom was abdominal pain, observed in 77 (62.6%) patients, followed by elevated hepatic transaminases in 70 (56.9%), hepatomegaly in 40 (32.5%), diarrhea in 26 (21.1%), and jaundice in 11 (8.9%) patients. The GIS involvement was associated with SLE in 82 (78.6%), while it resulted from drug-related adverse events in 35 (28.5%) patients or comorbidities in 6 (0.5%) patients.

Conclusion: GIS involvement should be considered in all childhood onset-SLE patients, especially in the presence of suggestive symptoms or elevated hepatic transaminases. It is also crucial to consider SLE in the differential diagnosis of GIS manifestations in children. Apart from GIS involvement directly associated with SLE, adverse events of drugs should be kept in mind.

探索儿童发病型系统性红斑狼疮的胃肠道表现--一项多中心研究的启示。
目的:系统性红斑狼疮(SLE)是一种可能累及胃肠道系统(GIS)的自身免疫性疾病。我们的目的是评估确诊为儿童期系统性红斑狼疮患者的胃肠道(GI)表现:研究队列包括来自16个儿科风湿病转诊部门的123名儿童期发病系统性红斑狼疮患者和GIS受累患者。所有参与者均符合系统性红斑狼疮国际合作诊所的标准:结果:在123名患者中,78人(63.4%)在最初确诊系统性红斑狼疮时表现出GIS受累,其余45人(36.6%)在中位12(3-140)个月后出现消化道症状。82名患者(66.7%)出现了与消化道相关的症状,而其余患者则是通过实验室评估确诊为消化道受累。77 名(62.6%)患者最初出现的 GIS 受累症状主要是腹痛,其次是 70 名(56.9%)患者肝脏转氨酶升高,40 名(32.5%)患者肝脏肿大,26 名(21.1%)患者腹泻,11 名(8.9%)患者出现黄疸。82例(78.6%)患者的GIS受累与系统性红斑狼疮有关,35例(28.5%)患者的GIS受累与药物相关不良事件有关,6例(0.5%)患者的GIS受累与合并症有关:结论:所有儿童期发病的系统性红斑狼疮患者都应考虑GIS受累,尤其是出现提示性症状或肝脏转氨酶升高时。在鉴别诊断儿童 GIS 表现时,考虑系统性红斑狼疮也至关重要。除了与系统性红斑狼疮直接相关的 GIS 受累外,还应注意药物的不良反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Lupus
Lupus 医学-风湿病学
CiteScore
4.20
自引率
11.50%
发文量
225
审稿时长
1 months
期刊介绍: The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…
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