Phytochemical screening along with in vitro antioxidant, antibacterial and anticancer activity of Senna auriculata (L.) bark extracts.

IF 2.2 4区医学 Q3 ENVIRONMENTAL SCIENCES

International Journal of Environmental Health Research Pub Date : 2024-08-27 DOI:10.1080/09603123.2024.2395446

Seemaisamy Revathi, Ammar B Altemimi, Sutikno Sutikno, Francesco Cacciola

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Abstract

This study aimed to evaluate the phytochemical content and biological properties of Senna auriculata (L.) Roxb. Four extracts-acetone, methanol, ethanol, and chloroform-were tested for antioxidant potential, enzymatic activity (peroxidase and polyphenol oxidase), antimicrobial, and anticancer effects. GC-MS analysis identified 34 bioactive compounds. The acetone extract exhibited the highest total alkaloid (5.8%), phenolic (752.78 ± 2.25 mg GAE/g), and flavonoid (285.78 ± 1.25 mg QE/g) content, along with the highest antioxidant (1489.42 ± 4.35 mg AAE/g) and enzyme activities. All extracts inhibited both Gram-positive and negative bacteria, with the acetone extract showing superior inhibition against S. aureus and B. subtilis. Additionally, the acetone and methanol extracts demonstrated anticancer effects on MDA-MB-231 breast cancer cells. These findings suggest that Senna auriculata has potential as a therapeutic agent for various diseases.

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番泻叶树皮提取物的植物化学筛选以及体外抗氧化、抗菌和抗癌活性。

本研究旨在评估番泻叶（Senna auriculata (L.) Roxb.对四种提取物--丙酮、甲醇、乙醇和氯仿--进行了抗氧化潜力、酶活性（过氧化物酶和多酚氧化酶）、抗菌和抗癌作用测试。GC-MS 分析确定了 34 种生物活性化合物。丙酮提取物的总生物碱（5.8%）、酚类（752.78 ± 2.25 毫克 GAE/克）和黄酮类（285.78 ± 1.25 毫克 QE/克）含量最高，抗氧化剂（1489.42 ± 4.35 毫克 AAE/克）和酶活性也最高。所有提取物都能抑制革兰氏阳性和阴性细菌，其中丙酮提取物对金黄色葡萄球菌和枯草杆菌的抑制作用更强。此外，丙酮和甲醇提取物对 MDA-MB-231 乳腺癌细胞也有抗癌作用。这些研究结果表明，箭毒番泻叶具有治疗各种疾病的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Environmental Health Research 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.70

自引率

3.10%

发文量

134

审稿时长

>12 weeks

期刊介绍： International Journal of Environmental Health Research ( IJEHR ) is devoted to the rapid publication of research in environmental health, acting as a link between the diverse research communities and practitioners in environmental health. Published articles encompass original research papers, technical notes and review articles. IJEHR publishes articles on all aspects of the interaction between the environment and human health. This interaction can broadly be divided into three areas: the natural environment and health – health implications and monitoring of air, water and soil pollutants and pollution and health improvements and air, water and soil quality standards; the built environment and health – occupational health and safety, exposure limits, monitoring and control of pollutants in the workplace, and standards of health; and communicable diseases – disease spread, control and prevention, food hygiene and control, and health aspects of rodents and insects. IJEHR is published in association with the International Federation of Environmental Health and includes news from the Federation of international meetings, courses and environmental health issues.

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