Waning Humoral Immune Response Following the Third and Fourth SARS-COV-2 Vaccine: A Cohort Study in Healthcare Workers

IF 4.3 4区 医学 Q1 INFECTIOUS DISEASES
Ahmet Furkan Süner, Gül Ergör, Derya Çağlayan, Neslişah Türe, Irmak Güzel, Çağlar Irmak, Elif Işık, Özgür Appak, Muammer Çelik, Gamze Öztürk, Sema Alp Çavuş, Arzu Sayiner, Alp Ergör, Yücel Demiral, Bulent Kilic
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引用次数: 0

Abstract

Background

This study is aimed at providing information about the timing of booster doses and antibody kinetics in healthcare workers.

Methods

This research extends a prospective cohort study conducted at Dokuz Eylul University Hospital in Turkey, covering the period from March 2021 to December 2021. During this timeframe, the antibody levels of the health workers were measured at four different time points. The associations of antibody levels with gender, age, occupation, body mass index (BMI), chronic disease, and smoking were analyzed.

Results

There was a significant difference between antibody levels in all four blood draws (p < 0.001). Antibody levels decreased in both those vaccinated with BNT162b2 (p < 0.001) and those vaccinated with CoronaVac (p = 0.002) until the fourth blood draw. There was a significant difference between those vaccinated with one and two doses of booster BNT162b2 before the third blood draw (p < 0.001), which continued at the fourth blood draw (p < 0.001). The antibody levels of those with an interval of 41–50 days between two vaccinations decreased significantly at the fourth blood draw (p < 0.001).

Conclusions

This study provides insight into the dynamics and persistence of antibody response after additional COVID-19 vaccine doses among healthcare workers. The longer the interval between booster doses may result in greater antibody levels being maintained over time, allowing for longer durations of protection.

Abstract Image

接种第三和第四针 SARS-COV-2 疫苗后体液免疫反应减弱:医护人员队列研究。
背景:本研究旨在提供有关医护人员加强剂量的时机和抗体动力学的信息:本研究旨在提供有关医护人员加强剂量的时机和抗体动力学的信息:本研究是土耳其 Dokuz Eylul 大学医院开展的一项前瞻性队列研究的延伸,时间跨度为 2021 年 3 月至 2021 年 12 月。在此期间,在四个不同的时间点测量了医护人员的抗体水平。分析了抗体水平与性别、年龄、职业、体重指数(BMI)、慢性病和吸烟的关系:结果:四次抽血的抗体水平均存在明显差异(P这项研究有助于深入了解医护人员在接种额外剂量的 COVID-19 疫苗后抗体反应的动态和持续性。加强剂量的间隔时间越长,抗体水平维持的时间就越长,从而延长保护时间。
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来源期刊
CiteScore
7.20
自引率
4.50%
发文量
120
审稿时长
6-12 weeks
期刊介绍: Influenza and Other Respiratory Viruses is the official journal of the International Society of Influenza and Other Respiratory Virus Diseases - an independent scientific professional society - dedicated to promoting the prevention, detection, treatment, and control of influenza and other respiratory virus diseases. Influenza and Other Respiratory Viruses is an Open Access journal. Copyright on any research article published by Influenza and Other Respiratory Viruses is retained by the author(s). Authors grant Wiley a license to publish the article and identify itself as the original publisher. Authors also grant any third party the right to use the article freely as long as its integrity is maintained and its original authors, citation details and publisher are identified.
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