Utility for Postoperative Respiratory Function of Transmediastinal Esophagectomy for Esophageal Carcinoma.

IF 1.8 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

In vivo Pub Date : 2024-09-01 DOI:10.21873/invivo.13702

Shutaro Sumiyoshi, Atsushi Shiozaki, Hitoshi Fujiwara, Hirotaka Konishi, Hiroyuki Inoue, Kazuya Takabatake, Keiji Nishibeppu, Jun Kiuchi, Taisuke Imamura, Kenji Nanishi, Hiroki Shimizu, Tomohiro Arita, Yusuke Yamamoto, Ryo Morimura, Takeshi Kubota, Eigo Otsuji

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引用次数: 0

Abstract

Background/aim: Esophagectomy for esophageal carcinoma (EC) is known to lead to deterioration of respiratory function (RF) due to thoracotomy and mediastinal lymph node dissection. This study aimed to evaluate the impact of transmediastinal esophagectomy (TME) on pulmonary function.

Patients and methods: We retrospectively analyzed the data of 102 patients with EC who underwent transthoracic esophagectomy (TTE) or TME and underwent RF tests within three months postoperatively at Kyoto Prefectural University of Medicine between 2014 and 2022. Perioperative pulmonary functions were evaluated based on vital capacity (VC) and forced expiratory volume in one second (FEV1.0).

Results: Among 102 patients undergoing esophagectomy, 12 (11.8%) patients were included in the TTE group, and the remaining 90 (88.2%) patients were included in the TME group. Neoadjuvant treatments were significantly more common in the TTE group (p=0.011), with more advanced tumor stages (p=0.017). The TME group had significantly lower estimated blood loss (p=0.015). RF after esophagectomy showed a decrease in VC, and VC of predicted (%VC). The decrease rate in VC, %VC, and FEV1.0 was significantly greater in the TTE group than in the TME group.

Conclusion: TME is a surgical procedure with a less severe postoperative decline in RF than TTE.

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食管癌经纵隔食管切除术术后呼吸功能的实用性。

背景/目的：众所周知，食管癌（EC）食管切除术会因开胸、纵隔淋巴结清扫而导致呼吸功能（RF）恶化。本研究旨在评估经纵隔食管切除术（TME）对肺功能的影响：我们回顾性分析了2014年至2022年间在京都府立医科大学接受经胸食管切除术（TTE）或TME并在术后三个月内接受射频检查的102例EC患者的数据。围手术期肺功能评估基于生命容量（VC）和一秒用力呼气容积（FEV1.0）：在102名接受食管切除术的患者中，12名（11.8%）患者被纳入TTE组，其余90名（88.2%）患者被纳入TME组。TTE 组患者接受新辅助治疗的比例明显更高（P=0.011），肿瘤分期也更晚（P=0.017）。TME组的估计失血量明显更少（p=0.015）。食管切除术后的射频显示出 VC 和预测 VC（%VC）的下降。TTE组VC、%VC和FEV1.0的下降率明显高于TME组：结论：与 TTE 相比，TME 是一种术后射频下降较轻的外科手术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

In vivo 医学-医学：研究与实验

CiteScore

4.20

自引率

4.30%

发文量

330

审稿时长

3-8 weeks

期刊介绍： IN VIVO is an international peer-reviewed journal designed to bring together original high quality works and reviews on experimental and clinical biomedical research within the frames of physiology, pathology and disease management. The topics of IN VIVO include: 1. Experimental development and application of new diagnostic and therapeutic procedures; 2. Pharmacological and toxicological evaluation of new drugs, drug combinations and drug delivery systems; 3. Clinical trials; 4. Development and characterization of models of biomedical research; 5. Cancer diagnosis and treatment; 6. Immunotherapy and vaccines; 7. Radiotherapy, Imaging; 8. Tissue engineering, Regenerative medicine; 9. Carcinogenesis.