Effect of cheese and casein phosphopeptide-amorphous calcium phosphate on erosive lesions of primary teeth enamel following exposure to amoxicillin and ibuprofen syrups: An in vitro study.

Q2 Dentistry
Dental Research Journal Pub Date : 2024-07-04 eCollection Date: 2024-01-01
Bahareh Yousefi, Majid Mehran, Yoones Sadabadi, Morteza Banakar, Roza Haghgoo
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引用次数: 0

Abstract

Background: The acidic component of liquid medicinal syrups used by pediatric patients may cause erosion and partial demineralization. This study aimed to evaluate the effect of cheese and casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) on erosive lesions of primary teeth enamel following exposure to amoxicillin and ibuprofen syrups.

Materials and methods: In this in vitro study, 60 noncarious deciduous molars were used. After measuring the surface microhardness of the samples, they were randomly separated into two groups and immersed in either amoxicillin or ibuprofen for 1 min three times per day. CPP-ACP, cheese, and artificial saliva were then applied to each of the three subgroups (n = 10). After each immersion time, 10 min of therapy was given. Between treatment intervals, the samples were kept in artificial saliva. The microhardness was remeasured after 1 week. Data were analyzed using SPSS software through repeated-measures ANOVA (α = 0.05).

Results: All samples' microhardness reduced considerably after immersion in liquid pharmaceuticals (amoxicillin [84.9 kgf/mm2] and ibuprofen [75.1 kgf/mm2]), but increased significantly following exposure to therapeutic solutions. There was no difference between the amoxicillin-cheese and amoxicillin-CPP-ACP subgroups (P = 0.975). A statistically insignificant difference was found between the ibuprofen group and the ibuprofen-CPP-ACP subgroup (P = 0.499).

Conclusion: As a result, cheese and CPP-ACP can be utilized to remineralize erosive lesions caused by amoxicillin or ibuprofen exposure.

奶酪和酪蛋白磷酸肽-无定形磷酸钙对暴露于阿莫西林和布洛芬糖浆后基牙釉质侵蚀性病变的影响:体外研究。
背景:儿童患者使用的液体糖浆中的酸性成分可能会导致腐蚀和部分脱矿。本研究旨在评估奶酪和酪蛋白磷酸肽-无定形磷酸钙(CPP-ACP)对接触阿莫西林和布洛芬糖浆后乳牙釉质侵蚀性病变的影响:在这项体外研究中,使用了 60 颗未龋坏的乳磨牙。在测量了样品的表面微硬度后,将它们随机分为两组,每天三次浸泡在阿莫西林或布洛芬中 1 分钟。然后将 CPP-ACP、奶酪和人工唾液分别涂抹在三个亚组(n = 10)上。每次浸泡后,进行 10 分钟的治疗。在治疗间隔期间,将样本保存在人工唾液中。1 周后重新测量微硬度。使用 SPSS 软件对数据进行重复测量方差分析(α = 0.05):所有样品的微硬度在浸入液体药物(阿莫西林[84.9 kgf/mm2]和布洛芬[75.1 kgf/mm2])后都明显降低,但在接触治疗溶液后则显著增加。阿莫西林-干酪亚组和阿莫西林-CPP-ACP 亚组之间没有差异(P = 0.975)。布洛芬组与布洛芬-CPP-ACP 亚组之间的差异在统计学上不显著(P = 0.499):因此,奶酪和 CPP-ACP 可用于修复因接触阿莫西林或布洛芬而引起的侵蚀性病变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Dental Research Journal
Dental Research Journal Dentistry-Dentistry (all)
CiteScore
1.70
自引率
0.00%
发文量
70
审稿时长
52 weeks
期刊介绍: Dental Research Journal, a publication of Isfahan University of Medical Sciences, is a peer-reviewed online journal with Bimonthly print on demand compilation of issues published. The journal’s full text is available online at http://www.drjjournal.net. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. The journal will cover technical and clinical studies related to health, ethical and social issues in field of Dentistry. Articles with clinical interest and implications will be given preference.
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