Sensitisation to the acrylate co-polymers glyceryl acrylate/acrylic acid co-polymer, sodium polyacrylate and acrylates/C10-30 alkyl acrylate cross-polymer (Carbopol®) is rare

IF 4.8 1区医学 Q2 ALLERGY

Contact Dermatitis Pub Date : 2024-08-26 DOI:10.1111/cod.14679

Livia F. Soriano, M. M. U. Chowdhury, Philippa Cousen, Simon Dawe, Sharizan A. Ghaffar, Adam Haworth, Catherine R. Holden, Aoife Hollywood, Graham A. Johnston, Stephen Kirk, Avad A. Mughal, David I. Orton, Robin Parker, Asha Rajeev, Krisztina Scharrer, Aparna Sinha, Natalie M. Stone, Donna Thompson, Sarah Wakelin, Heather Whitehouse, Catriona Wootton, Deirdre A. Buckley

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引用次数: 0

Abstract

Background

Acrylate polymers and cross-polymers (ACPs) are frequently used cosmetic ingredients. The British Society for Cutaneous Allergy (BSCA) and the UK Cosmetic, Toiletry and Perfumery Association (CTPA) collaborated to investigate the allergenic potential of three commonly-used ACPs.

Objectives

The objective of this study is to determine the prevalence of allergic contact dermatitis (ACD) to three ACPs: glyceryl acrylate/acrylic acid co-polymer, sodium polyacrylate, and acrylates/C10-30 alkyl acrylate cross-polymer (Carbopol®).

Materials and Methods

The BSCA prospectively audited data collected from 20 centres in the UK and Ireland between 1st September 2021 and 1st September 2022. Patients with suspected ACD to (meth)acrylates, with facial dermatitis, or consecutive patients, were patch tested to glyceryl acrylate/acrylic acid co-polymer 10% aqueous (aq.) sodium polyacrylate 2% aq., and to acrylates/C10-30 alkyl acrylate cross-polymer 2% aq. (Carbopol®). The frequencies of positive, irritant, and doubtful reactions were recorded.

Results

In total, 1302 patients were patch tested. To glyceryl acrylate/acrylic acid co-polymer, there was one doubtful reaction in a patient allergic to multiple (meth)acrylates, and one irritant. To sodium polyacrylate, there were four irritant reactions, one doubtful, and one positive reaction; in all cases, relevance was unknown and there was no demonstrable (meth)acrylate allergy. There were no reactions to Carbopol®.

Conclusions

Sensitisation to these concentrations of the three tested ACPs is rare. Elicitation of dermatitis in (meth)acrylate-sensitised patients by exposure to these three ACPs appears unlikely.

Abstract Image

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对丙烯酸酯共聚物甘油丙烯酸酯/丙烯酸共聚物、聚丙烯酸钠和丙烯酸酯/C10-30 烷基丙烯酸酯交联聚合物（Carbopol®）过敏的情况很少见。

背景：丙烯酸酯聚合物和交联聚合物 (ACP) 是常用的化妆品成分。英国皮肤过敏协会（BSCA）和英国化妆品、洗涤用品和香水协会（CTPA）合作调查了三种常用 ACP 的致敏可能性：本研究旨在确定三种ACP（甘油丙烯酸酯/丙烯酸共聚物、聚丙烯酸钠和丙烯酸酯/C10-30烷基丙烯酸酯交联聚合物（Carbopol®））的过敏性接触性皮炎（ACD）发病率：BSCA 对 2021 年 9 月 1 日至 2022 年 9 月 1 日期间从英国和爱尔兰 20 个中心收集的数据进行了前瞻性审核。对疑似对（甲基）丙烯酸酯过敏的面部皮炎患者或连续患者进行了甘油丙烯酸酯/丙烯酸共聚物10%水溶液（aq.）、聚丙烯酸钠2%水溶液（aq.）和丙烯酸酯/C10-30烷基丙烯酸酯交联聚合物2%水溶液（Carbopol®）的贴片测试。记录了阳性反应、刺激性反应和可疑反应的频率：共有 1302 名患者接受了贴片测试。一名对多种（甲基）丙烯酸酯过敏的患者对丙烯酸甘油酯/丙烯酸共聚物产生了一种可疑反应，还有一种刺激反应。聚丙烯酸钠有四种刺激性反应、一种可疑反应和一种阳性反应；在所有情况下，相关性不明，也没有明显的（甲基）丙烯酸酯过敏症。Carbopol®没有引起任何反应：结论：对这些浓度的三种受测 ACP 产生过敏反应的情况非常罕见。接触这三种ACP似乎不太可能导致对（甲基）丙烯酸酯过敏的患者出现皮炎。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Contact Dermatitis 医学-过敏

CiteScore

4.60

自引率

30.90%

发文量

227

审稿时长

4-8 weeks

期刊介绍： Contact Dermatitis is designed primarily as a journal for clinicians who are interested in various aspects of environmental dermatitis. This includes both allergic and irritant (toxic) types of contact dermatitis, occupational (industrial) dermatitis and consumers" dermatitis from such products as cosmetics and toiletries. The journal aims at promoting and maintaining communication among dermatologists, industrial physicians, allergists and clinical immunologists, as well as chemists and research workers involved in industry and the production of consumer goods. Papers are invited on clinical observations, diagnosis and methods of investigation of patients, therapeutic measures, organisation and legislation relating to the control of occupational and consumers".