Relationship of Hypothyroidism with Alopecia Areata and Androgenetic Alopecia: Insights from a Two-Sample Mendelian Randomization Study.

IF 1.9 4区医学 Q3 DERMATOLOGY

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-08-22 eCollection Date: 2024-01-01 DOI:10.2147/CCID.S474168

Gongjie Zhang, Xinlyu Huang, Hanlin Li, Huizi Gong, Yabin Zhou, Fang Liu

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Abstract

Background: Hair loss is common in hypothyroidism patients. However, the link with alopecia areata (AA) and androgenetic alopecia (AGA) is unclear. Previous observational studies have presented completely opposite results. This study aims to causally link hypothyroidism with AA and AGA.

Methods: A two-sample Mendelian Randomization (MR) study, utilizing data from FinnGen Consortium, investigated the causal link between hypothyroidism and AA and AGA. We employed Inverse Variance Weighted (IVW), MR-Egger, Weighted Median, Simple Mode, and Weighted Mode to assess the risk association.

Results: The discovery samples included 13,429 hypothyroidism cases (94,436 controls), 767 alopecia areata cases (394,105 controls), and 220 androgenetic alopecia cases (219,249 controls). MR analysis showed a causal link between hypothyroidism and AA, with significant results from IVW (OR, 1.34; CI, 1.16-1.56; P = 0.0001), MR-Egger (OR, 1.56; CI, 1.09-2.23; P = 0.0240), and weighted median (OR, 1.34; CI, 1.06-1.69; P = 0.0140). However, no clear causal relationship was found between genetically predicted hypothyroidism and AGA risk (p > 0.05).

Conclusion: The results show hypothyroidism causally associated with AA onset, but not AGA. These findings address contentious issues in observational studies. Comprehensive thyroid function assessments are crucial for AA patients, emphasizing thorough clinical examinations' importance.

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甲状腺机能减退与大面积脱发和雄激素性脱发的关系：双样本孟德尔随机研究的启示

背景：脱发在甲状腺功能减退症患者中很常见。然而，脱发与斑秃（AA）和雄激素性脱发（AGA）之间的关系尚不清楚。以往的观察性研究得出了完全相反的结果。本研究旨在探讨甲状腺功能减退症与 AA 和 AGA 的因果关系：方法：利用芬兰基因联盟（FinnGen Consortium）的数据进行了一项双样本孟德尔随机化（Mendelian Randomization，MR）研究，调查甲状腺功能减退症与 AA 和 AGA 之间的因果关系。我们采用了反方差加权（IVW）、MR-Egger、加权中位数、简单模式和加权模式来评估风险关联：发现样本包括 13,429 个甲状腺功能减退症病例（94,436 个对照组）、767 个斑秃病例（394,105 个对照组）和 220 个雄激素性脱发病例（219,249 个对照组）。MR分析表明甲状腺功能减退症与AA之间存在因果关系，IVW（OR，1.34；CI，1.16-1.56；P = 0.0001）、MR-Egger（OR，1.56；CI，1.09-2.23；P = 0.0240）和加权中位数（OR，1.34；CI，1.06-1.69；P = 0.0140）的分析结果均显著。然而，在遗传预测的甲状腺功能减退症与 AGA 风险之间没有发现明显的因果关系（P > 0.05）：结果表明，甲状腺功能减退症与 AA 发病有因果关系，但与 AGA 无关。这些发现解决了观察性研究中的争议问题。对AA患者进行全面的甲状腺功能评估至关重要，这强调了全面临床检查的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical, Cosmetic and Investigational Dermatology Medicine-Dermatology

CiteScore

2.80

自引率

4.30%

发文量

353

审稿时长

16 weeks

期刊介绍： Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.