Heme oxygenase-1 binds gasdermin D to inhibit airway epithelium pyroptosis in allergic asthma

IF 6.1 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Apoptosis Pub Date : 2024-08-27 DOI:10.1007/s10495-024-02016-6

Jiajia Lv, Min Wu, Zhenwei Xia

引用次数: 0

Abstract

This study explores how heme oxygenase-1 affects allergic airway inflammation, specifically focusing on airway epithelium pyroptosis. Findings suggest heme oxygenase-1 binds gasdermin D C-terminal to limit release of N-terminal, which affects NLRP3-caspase 1-gasdermin D trimer formation. This enhances comprehension of anti-inflammatory activity of heme oxygenase-1 in allergic disorders.

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血红素加氧酶-1 可与气敏素 D 结合，抑制过敏性哮喘患者气道上皮细胞的脓毒症。

本研究探讨了血红素加氧酶-1如何影响过敏性气道炎症，特别是气道上皮细胞的脓毒症。研究结果表明，血红素加氧酶-1能与gasdermin D C端结合，限制N端的释放，从而影响NLRP3-caspase 1-gasdermin D三聚体的形成。这有助于理解血红素加氧酶-1在过敏性疾病中的抗炎活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Apoptosis 生物-生化与分子生物学

CiteScore

9.10

自引率

4.20%

发文量

审稿时长

1 months

期刊介绍： Apoptosis, a monthly international peer-reviewed journal, focuses on the rapid publication of innovative investigations into programmed cell death. The journal aims to stimulate research on the mechanisms and role of apoptosis in various human diseases, such as cancer, autoimmune disease, viral infection, AIDS, cardiovascular disease, neurodegenerative disorders, osteoporosis, and aging. The Editor-In-Chief acknowledges the importance of advancing clinical therapies for apoptosis-related diseases. Apoptosis considers Original Articles, Reviews, Short Communications, Letters to the Editor, and Book Reviews for publication.