Whole tomato lipidic extract improved sperm quality in obese rats induced by a high-carbohydrate diet.

IF 3.2 2区 医学 Q1 ANDROLOGY
Andrology Pub Date : 2024-08-27 DOI:10.1111/andr.13736
Vázquez Mendoza Luis Heriberto, Mailloux Salinas Patrick, Campos Pérez Elihu, Guadalupe Bravo, Arias Chávez David Julian
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Abstract

Background: Obesity represents a risk in the development of metabolic and oxidative stress (OS), as well as in male infertility. There is still no pharmacological treatment for obesity-induced male infertility, but the use of natural antioxidants has been proposed as a treatment.

Objective: The aim of this work is to evaluate the effect of a whole tomato lipid extract on rats that decreased their fertility and spermatogenesis after being induced obese with a high carbohydrate diet.

Materials and methods: One hundred fourteen male Wistar rats of 12 weeks of age were used. Two groups were randomly formed non-obese control group (C, n = 54) and obese group (Ob, n = 54) that received 30% w/v sucrose solution for 3 months. Subsequently, the C and Ob group were divided into two groups: vehicle (C-Vh and Ob-Vh) that received corn oil as vehicle and tomato lipid extract (C-Ex and Ob-Ex) that received whole tomato lipid extract. The groups that received a hypercaloric diet had a gain in visceral and retroperitoneal adipose tissue, an increase in total cholesterol and triglyceride levels, increased OS in the testis, and lesions in testicular histology, as well as a reduction in testicular size and sperm quality parameters (motility, viability, and concentration).

Results: Treatment with whole tomato lipid extract significantly decreased the weight of gonadal adipose tissue and OS, maintained testicular size, showed a significant increase in sperm quality parameters and improved histology of seminiferous tubules.

Conclusions: These results demonstrate a greater therapeutic and beneficial effect of the tomato lipid extract on sperm quality parameters in obese rats and therefore on fertility.

全番茄脂质提取物可改善高碳水化合物饮食诱发的肥胖大鼠的精子质量。
背景:肥胖是导致新陈代谢和氧化应激(OS)以及男性不育的一个风险因素。对于肥胖引起的男性不育症,目前还没有药物治疗方法,但有人建议使用天然抗氧化剂作为治疗方法:本研究旨在评估全番茄脂质提取物对高碳水化合物饮食诱导肥胖后生育能力和精子发生能力下降的大鼠的影响:材料和方法:使用 144 只 12 周大的雄性 Wistar 大鼠。随机分为两组,非肥胖对照组(C,n = 54)和肥胖组(Ob,n = 54),分别接受 30% w/v 蔗糖溶液治疗 3 个月。随后,C 组和肥胖组又分为两组:以玉米油为载体的载体组(C-Vh 和 Ob-Vh)和以番茄全脂提取物为载体的番茄脂提取物组(C-Ex 和 Ob-Ex)。结果发现,接受高热量饮食的组内脏和腹膜后脂肪组织增加,总胆固醇和甘油三酯水平升高,睾丸OS增加,睾丸组织学发生病变,睾丸大小和精子质量指标(活力、存活率和浓度)降低:结果:用全番茄脂质提取物治疗可明显降低性腺脂肪组织的重量和OS,保持睾丸大小,精子质量指标显著提高,并改善曲细精管的组织学:这些结果表明,番茄脂质提取物对肥胖大鼠的精子质量指标有更大的治疗作用和益处,因此对生育能力也有更大的影响。
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来源期刊
Andrology
Andrology ANDROLOGY-
CiteScore
9.10
自引率
6.70%
发文量
200
期刊介绍: Andrology is the study of the male reproductive system and other male gender related health issues. Andrology deals with basic and clinical aspects of the male reproductive system (gonads, endocrine and accessory organs) in all species, including the diagnosis and treatment of medical problems associated with sexual development, infertility, sexual dysfunction, sex hormone action and other urological problems. In medicine, Andrology as a specialty is a recent development, as it had previously been considered a subspecialty of urology or endocrinology
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