The epigenetic mechanism of metabolic risk in bipolar disorder

IF 8 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Obesity Reviews Pub Date : 2024-08-26 DOI:10.1111/obr.13816

Kexin Huang, Sujuan Li, Min Yang, Ziwei Teng, Baoyan Xu, Bolun Wang, Jindong Chen, Liping Zhao, Haishan Wu

引用次数: 0

Abstract

Bipolar disorder (BD) is a complex and severe mental illness that causes significant suffering to patients. In addition to the burden of depressive and manic symptoms, patients with BD are at an increased risk for metabolic syndrome (MetS). MetS includes factors associated with an increased risk of atherosclerotic cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM), which may increase the mortality rate of patients with BD. Several studies have suggested a link between BD and MetS, which may be explained at an epigenetic level. We have focused on epigenetic mechanisms to review the causes of metabolic risk in BD.

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双相情感障碍代谢风险的表观遗传机制。

躁郁症（BD）是一种复杂而严重的精神疾病，给患者带来巨大痛苦。除了抑郁和躁狂症状带来的负担外，躁郁症患者患代谢综合征（MetS）的风险也在增加。代谢综合征包括与动脉粥样硬化性心血管疾病（CVD）和 2 型糖尿病（T2DM）风险增加相关的因素，可能会增加 BD 患者的死亡率。一些研究表明，BD 和 MetS 之间存在联系，这可能可以从表观遗传学的角度来解释。我们将重点放在表观遗传机制上，以回顾 BD 代谢风险的原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity Reviews 医学-内分泌学与代谢

CiteScore

19.30

自引率

1.10%

发文量

130

审稿时长

1 months

期刊介绍： Obesity Reviews is a monthly journal publishing reviews on all disciplines related to obesity and its comorbidities. This includes basic and behavioral sciences, clinical treatment and outcomes, epidemiology, prevention and public health. The journal should, therefore, appeal to all professionals with an interest in obesity and its comorbidities. Review types may include systematic narrative reviews, quantitative meta-analyses and narrative reviews but all must offer new insights, critical or novel perspectives that will enhance the state of knowledge in the field. The editorial policy is to publish high quality peer-reviewed manuscripts that provide needed new insight into all aspects of obesity and its related comorbidities while minimizing the period between submission and publication.