Indoline hemiaminals: a platform for accessing anthranilic acid derivatives through oxidative deformylation†

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2024-09-18 DOI:10.1039/d4ob01218f

Keisuke Tokushige , Yuito Kobori , Shota Asai , Takumi Abe

引用次数: 0

Abstract

2-Aminobenzoyl chlorides possess both a nucleophilic nitrogen atom and an electrophilic carbonyl group, and thus selective acylation of nucleophiles is challenging; self-dimerization and sluggish reactions occur. Herein, we introduce a new synthetic protocol using 2-aminobenzoyl surrogates, allowing concise entry to decorated 2-aminobenzoyl derivatives in the absence of transition metals, acid chlorides, and specific reagents.

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吲哚啉半二胺：通过氧化变形获得花苯胺酸衍生物的平台。

2- 氨基苯甲酰氯同时具有亲核的氮原子和亲电的羰基，因此亲核物的选择性酰化具有挑战性，会出现自嵌合和反应迟缓的现象。在此，我们介绍了一种使用 2-氨基苯甲酰基替代物的新合成方案，在没有过渡金属、酸性氯化物和特定试剂的情况下，可以简便地进入装饰的 2-氨基苯甲酰基衍生物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.