Potential for reducing dementia risk: association of the CAIDE score with additional lifestyle components from the LIBRA score in a population at high risk of dementia.

IF 2.8 3区 医学 Q3 GERIATRICS & GERONTOLOGY
Mandy Claus, Melanie Luppa, Andrea Zülke, Iris Blotenberg, Maria Isabel Cardona, Juliane Döhring, Catharina Escales, Robert Philipp Kosilek, Anke Oey, Isabel Zöllinger, Christian Brettschneider, David Czock, Thomas Frese, Jochen Gensichen, Wolfgang Hoffmann, Hanna Kaduszkiewicz, Hans-Helmut König, Birgitt Wiese, Jochen René Thyrian, Steffi G Riedel-Heller
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引用次数: 0

Abstract

Objectives: Various dementia risk scores exist that assess different factors. We investigated the association between the Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) score and modifiable risk factors in the Lifestyle for Brain Health (LIBRA) score in a German population at high risk of Alzheimer's disease.

Method: Baseline data of 807 participants of AgeWell.de (mean age: 68.8 years (SD = 4.9)) were analysed. Stepwise multivariable regression was used to examine the association between the CAIDE score and additional risk factors of the LIBRA score. Additionally, we examined the association between dementia risk models and cognitive performance, as measured by the Montreal Cognitive Assessment.

Results: High cognitive activity (β = -0.016, p < 0.001) and high fruit and vegetable intake (β = -0.032, p < 0.001) correlated with lower CAIDE scores, while diabetes was associated with higher CAIDE scores (β = 0.191; p = 0.032). Although all were classified as high risk on CAIDE, 31.5% scored ≤0 points on LIBRA, indicating a lower risk of dementia. Higher CAIDE and LIBRA scores were associated with lower cognitive performance.

Conclusion: Regular cognitive activities and increased fruit and vegetable intake were associated with lower CAIDE scores. Different participants are classified as being at-risk based on the dementia risk score used.

降低痴呆症风险的潜力:在痴呆症高风险人群中,CAIDE 评分与 LIBRA 评分中的其他生活方式要素的关联。
目的:目前有各种痴呆症风险评分,评估不同的因素。我们在德国阿尔茨海默病高风险人群中调查了心血管风险因素、衰老和痴呆症发病率(CAIDE)评分与脑健康生活方式(LIBRA)评分中可改变的风险因素之间的关联:分析了 AgeWell.de 807 名参与者(平均年龄:68.8 岁(SD = 4.9))的基线数据。采用逐步多变量回归法研究 CAIDE 评分与 LIBRA 评分的其他风险因素之间的关联。此外,我们还研究了痴呆症风险模型与蒙特利尔认知评估(Montreal Cognitive Assessment)测量的认知能力之间的关联:高认知活动(β = -0.016,p p = 0.032)。虽然所有人都被归类为 CAIDE 的高危人群,但有 31.5% 的人在 LIBRA 中得分≤0 分,表明患痴呆症的风险较低。CAIDE和LIBRA得分越高,认知能力越差:结论:定期进行认知活动以及增加水果和蔬菜摄入量与较低的 CAIDE 分数有关。根据所使用的痴呆风险评分,不同的参与者被划分为高危人群。
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来源期刊
Aging & Mental Health
Aging & Mental Health 医学-精神病学
CiteScore
7.00
自引率
2.90%
发文量
176
审稿时长
4-8 weeks
期刊介绍: Aging & Mental Health provides a leading international forum for the rapidly expanding field which investigates the relationship between the aging process and mental health. The journal addresses the mental changes associated with normal and abnormal or pathological aging, as well as the psychological and psychiatric problems of the aging population. The journal also has a strong commitment to interdisciplinary and innovative approaches that explore new topics and methods. Aging & Mental Health covers the biological, psychological and social aspects of aging as they relate to mental health. In particular it encourages an integrated approach for examining various biopsychosocial processes and etiological factors associated with psychological changes in the elderly. It also emphasizes the various strategies, therapies and services which may be directed at improving the mental health of the elderly and their families. In this way the journal promotes a strong alliance among the theoretical, experimental and applied sciences across a range of issues affecting mental health and aging. The emphasis of the journal is on rigorous quantitative, and qualitative, research and, high quality innovative studies on emerging topics.
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