Life's essential 8 and risk of subclinical atherosclerosis progression: a prospective cohort study.

IF 1.8 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Geriatric Cardiology Pub Date : 2024-07-28 DOI:10.26599/1671-5411.2024.07.005

Shi-Yu Zhou, Fang-Chao Liu, Shu-Feng Chen, Jian-Xin Li, Jie Cao, Ke-Yong Huang, Zheng-Hao Tang, Feng-Chao Liang, Dong-Sheng Hu, Lian-Cheng Zhao, Ying Li, Jian-Feng Huang, Xiang-Feng Lu, Bin Lu, Dong-Feng Gu

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引用次数: 0

Abstract

Background: Previous studies have demonstrated the benefits of ideal cardiovascular health (CVH) in reducing cardiovascular risk. However, its role in subclinical atherosclerosis (SA) progression remains unclear. We aim to examine the association of CVH, estimated by the American Heart Association's new Life's Essential 8 (LE8), with the progression of SA.

Methods: This prospective cohort study was conducted among 972 asymptomatic Chinese participants and followed up for 5.7 years. The LE8 score (range, 0-100) consisted of blood pressure, lipids, glucose, body mass index, smoking status, diet health, physical activity and sleep health was evaluated in 1998 and 2008-2009. Progression of SA was determined by carotid plaque and coronary artery calcification (CAC) in 2008-2009 and 2013-2014. Log-binomial regression model was used to estimate the association of LE8 score with SA progression.

Results: Each 10 points increment in LE8 score was associated with 15.2% (RR: 0.848, 95% CI: 0.797-0.902), 17.7% (RR: 0.823, 95% CI: 0.766-0.884) and 12.0% (RR: 0.880, 95% CI: 0.845-0.916) lower risks of carotid plaque, CAC and overall SA progression, respectively. Compared with participants with non-ideal CVH at both visits, the participants with ideal CVH at both visits had 39.1% (RR: 0.609, 95% CI: 0.494-0.752), 41.0% (RR: 0.590, 95% CI: 0.456-0.764) and 29.7% (RR: 0.703, 95% CI: 0.598-0.825) lower risks of carotid plaque, CAC and overall SA progression, respectively.

Conclusions: Higher LE8 scores were associated with lower risks of SA progression. Besides, long-term maintenance of optimal CVH was more beneficial to prevent SA progression.

查看原文本刊更多论文

生活必需品 8 与亚临床动脉粥样硬化进展风险：一项前瞻性队列研究。

背景：以往的研究表明，理想的心血管健康（CVH）有利于降低心血管风险。然而，其在亚临床动脉粥样硬化（SA）进展中的作用仍不清楚。我们的目的是研究根据美国心脏协会新的生命基本指标 8（LE8）估算的 CVH 与亚临床动脉粥样硬化进展的关系：这项前瞻性队列研究对 972 名无症状的中国参与者进行了为期 5.7 年的随访。1998年和2008-2009年的LE8评分（范围0-100）包括血压、血脂、血糖、体重指数、吸烟状况、饮食健康、体力活动和睡眠健康。2008-2009年和2013-2014年，通过颈动脉斑块和冠状动脉钙化（CAC）确定了SA的进展情况。采用对数二叉回归模型估计LE8评分与SA进展的关系：LE8得分每增加10分，颈动脉斑块、CAC和整体SA恶化的风险分别降低15.2%（RR：0.848，95% CI：0.797-0.902）、17.7%（RR：0.823，95% CI：0.766-0.884）和12.0%（RR：0.880，95% CI：0.845-0.916）。与两次检查均为非理想CVH的参与者相比，两次检查均为理想CVH的参与者颈动脉斑块、CAC和总体SA进展的风险分别降低了39.1%（RR：0.609，95% CI：0.494-0.752）、41.0%（RR：0.590，95% CI：0.456-0.764）和29.7%（RR：0.703，95% CI：0.598-0.825）：结论：LE8评分越高，SA恶化的风险越低。结论：LE8评分越高，SA进展的风险越低。此外，长期保持最佳CVH更有利于预防SA进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Geriatric Cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-GERIATRICS & GERONTOLOGY

CiteScore

3.30

自引率

4.00%

发文量

1161

期刊介绍： JGC focuses on both basic research and clinical practice to the diagnosis and treatment of cardiovascular disease in the aged people, especially those with concomitant disease of other major organ-systems, such as the lungs, the kidneys, liver, central nervous system, gastrointestinal tract or endocrinology, etc.

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