Lung function parameters are associated with acute mountain sickness and are improved at high and extreme altitude

IF 1.9 4区医学 Q3 PHYSIOLOGY

Respiratory Physiology & Neurobiology Pub Date : 2024-08-23 DOI:10.1016/j.resp.2024.104318

Reto Reiser , Anne-Kathrin Brill , Christos T. Nakas , Urs Hefti , David Berger , Eveline Perret Hoigné , Hans-Joachim Kabitz , Tobias M. Merz , Jacqueline Pichler Hefti

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引用次数: 0

Abstract

At altitude, factors such as decreased barometric pressure, low temperatures, and acclimatization might affect lung function.

The effects of exposure and acclimatization to high-altitude on lung function were assessed in 39 subjects by repetitive spirometry up to 6022 m during a high-altitude expedition. Subjects were classified depending on the occurrence of acute mountain sickness (AMS) and summit success to evaluate whether lung function relates to successful climb and risk of developing AMS.

Peak expiratory flow (PEF), forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1) increased with progressive altitude (max. +20.2 %pred, +9.3 %pred, and +6.7 %pred, all p<0.05). Only PEF improved with acclimatization (BC1 vs. BC2, +7.2 %pred, p=0.044). At altitude FEV1 (p=0.008) and PEF (p<0.001) were lower in the AMS group.

The risk of developing AMS was associated with lower baseline PEF (p<0.001) and longitudinal changes in PEF (p=0.008) and FEV1 (p<0.001). Lung function was not related to summit success (7126 m). Improvement in PEF after acclimatization might indicate respiratory muscle adaptation.

查看原文本刊更多论文

肺功能参数与急性高山病有关，在高海拔和极高海拔地区会得到改善。

在高海拔地区，气压下降、低温和适应性训练等因素可能会影响肺功能。在一次高海拔探险中，39 名受试者在海拔 6022 米处进行了重复肺活量测定，评估了暴露于高海拔环境和适应高海拔环境对肺功能的影响。根据急性登山病（AMS）的发生率和登顶成功率对受试者进行分类，以评估肺功能是否与成功登顶和发生急性登山病的风险有关。峰值呼气流量（PEF）、用力肺活量（FVC）和1秒钟用力呼气容积（FEV1）随着海拔高度的升高而增加（最大值分别为+20.2%pred、+9.3%pred和+6.7%pred，所有p

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Respiratory Physiology & Neurobiology 医学-呼吸系统

CiteScore

4.80

自引率

8.70%

发文量

104

审稿时长

54 days

期刊介绍： Respiratory Physiology & Neurobiology (RESPNB) publishes original articles and invited reviews concerning physiology and pathophysiology of respiration in its broadest sense. Although a special focus is on topics in neurobiology, high quality papers in respiratory molecular and cellular biology are also welcome, as are high-quality papers in traditional areas, such as: -Mechanics of breathing- Gas exchange and acid-base balance- Respiration at rest and exercise- Respiration in unusual conditions, like high or low pressure or changes of temperature, low ambient oxygen- Embryonic and adult respiration- Comparative respiratory physiology. Papers on clinical aspects, original methods, as well as theoretical papers are also considered as long as they foster the understanding of respiratory physiology and pathophysiology.