The outcomes of parathyroid gland autotransplantation during thyroid surgery: a systematic review, meta-analysis and trial sequential analysis.

IF 3.7 3区医学 Q2 Medicine

Endocrine Pub Date : 2024-08-24 DOI:10.1007/s12020-024-04011-y

Georgios Koimtzis, Leandros Stefanopoulos, Georgios Geropoulos, Theodosios Papavramidis

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引用次数: 0

Abstract

Purpose: Thyroidectomy is the treatment of choice for malignant thyroid diseases as well as for benign conditions who cannot be treated medically. The most common complication following thyroidectomy is hypocalcaemia and hypoparathyroidism that usually results from accidental damage or removal of one or more parathyroid glands. Parathyroid gland autotransplantation has been one of the most common intraoperative strategies applied to tackle this problem. The aim of this study is to assess whether parathyroid auto trasnplantation is associated with a decrease in postoperative hypoparathyroidism following thyroidectomy.

Methods: We conducted a thorough systematic review and meta-analysis of relevant studies published up to February 2024 in MEDLINE, Scopus, Embase and Cochrane Library databases. We compared the incidence of postoperative hypoparathyroidism between the group of patients who underwent autotransplantation and the patients were the parathyroid glands were preserved in situ. A trial sequential analysis was performed subsequently to confirm the findings.

Results: Eighteen studies fulfilled all the inclusion criteria and were ultimately included in our study. The total number of patients was 8,182 with 4,029 receiving parathyroid gland autotransplantation. Autotransplantation was associated with a higher incidence of immediate (within 24 h) and transient hypoparathyroidism (RR 1.58, 1.45-1.73, CI 95%, p < 0.00 and RR 1.60, 1.47-1.76, CI 95%, p < 0.001, respectively). However, it did not affect the rate of permanent postoperative hypoparathyroidism (RR 0.85, 0.51-1.41, CI 95%, p = 0.54). The subsequent trial sequential analysis confirmed these findings.

Conclusion: Parathyroid autotransplantation does not lead to a decrease in the rate of permanent post-thyroidectomy hypoparathyroidism. The most important factor to decrease its incidence remains the accurate identification and preservation of the parathyroid glands intraoperatively.

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甲状腺手术中甲状旁腺自体移植的结果：系统综述、荟萃分析和试验序列分析。

目的：甲状腺切除术是恶性甲状腺疾病以及无法通过药物治疗的良性疾病的首选治疗方法。甲状腺切除术后最常见的并发症是低钙血症和甲状旁腺功能减退症，这通常是由于一个或多个甲状旁腺意外受损或被切除所致。甲状旁腺自体移植是解决这一问题最常用的术中策略之一。本研究旨在评估甲状旁腺自体移植是否与甲状腺切除术后甲状旁腺功能减退症的减少有关：我们对MEDLINE、Scopus、Embase和Cochrane图书馆数据库中截至2024年2月发表的相关研究进行了全面的系统回顾和荟萃分析。我们比较了接受自体移植和原位保留甲状旁腺的患者术后甲状旁腺功能减退的发生率。随后进行了试验序列分析，以确认研究结果：18项研究符合所有纳入标准，最终被纳入我们的研究。患者总数为8182人，其中4029人接受了甲状旁腺自体移植手术。自体移植与即刻（24小时内）和一过性甲状旁腺功能减退症的发生率较高有关（RR 1.58, 1.45-1.73, CI 95%, p 结论：甲状旁腺自体移植与即刻（24小时内）和一过性甲状旁腺功能减退症的发生率较高有关：甲状旁腺自体移植并不能降低甲状腺切除术后永久性甲状旁腺功能减退症的发生率。降低其发生率的最重要因素仍然是术中准确识别和保留甲状旁腺。

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来源期刊

Endocrine 医学-内分泌学与代谢

CiteScore

6.40

自引率

5.40%

发文量

期刊介绍： Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.