Warthin tumor concomitant with mantle cell lymphoma: a case report and review of literature.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Hai-Chao Tong, Shuang Ma, Lan Chen, Xiangyun Meng, Ying-Chun Li, Le-Yao Li, Lingyun Dong, Wan-Lin Zhang, Tyler Wildes, Lian-He Yang, Endi Wang
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Abstract

Rationale: Warthin tumor (WT) is the second most common benign tumor in salivary gland. It has a slow growth rate and most frequently occurs in the parotid gland. Most patients present with an incidental finding of a painless mass inferior/anterior to the ear. Besides the epithelial component of the tumor, WT is characteristically associated with lymphoid stroma that is considered benign. While there have been a few reports of malignant transformation of the lymphoid components in WT, cases of WT concomitant with mantle cell lymphoma (MCL) are extremely rare. To the best of our knowledge, two cases have been described in the English literature. Herein, we report a case of WT concomitant with MCL in a 70-year-old female patient, and emphasize the importance of careful examination of lymphoid stroma in WT so that concurrent lymphoma is not missed.

Patient concerns: A 70-year-old Chinese woman with a 40-year history of cigarette smoking presented with a one year history of a right submaxillary mass with recent enlargement.

Diagnosis: Cervical ultrasound (US) and computed tomography (CT) scans of the neck revealed a well-circumscribed mass in the right parotid with a maximum diameter of 3.1 cm. Surgical resection of the mass was performed. Histopathological examination revealed a characteristic double-layer of neoplastic epithelium with prominent lymphoid stroma, suggesting WT. In addition, morphology and immunohistochemistry studies confirmed the coexistence of MCL. Thereafter, the final diagnosis of this case was WT concomitant with MCL.

Interventions: The patient was staged as stage I after clinical assessment. Due to the slow growth of parotid lesions, close observation was decided with periodic clinical and radiological monitoring.

Outcomes: Currently, the patient demonstrates a stable disease by clinical evaluation.

Lessons: To the best of our knowledge, reported cases of WT concomitant with MCL are very rare. This case highlights the importance of a comprehensive assessment of the lymphoid stroma of WT to avoid missed diagnosis of a lymphoma component in a collision tumor.

Warthin肿瘤并发套细胞淋巴瘤:病例报告和文献综述。
理论依据:Warthin瘤(WT)是唾液腺中第二常见的良性肿瘤。它生长缓慢,最常发生在腮腺。大多数患者都是偶然发现耳下/耳前有一无痛性肿块。除了肿瘤的上皮成分外,WT 通常还伴有被认为是良性的淋巴基质。虽然有少数报道称 WT 中的淋巴成分发生了恶性转化,但 WT 同时伴有套细胞淋巴瘤(MCL)的病例却极为罕见。据我们所知,英文文献中描述过两例。在此,我们报告了一例70岁女性患者WT合并MCL的病例,并强调了仔细检查WT淋巴基质的重要性,以免漏诊并发淋巴瘤:一名有40年吸烟史的70岁中国女性患者,因右侧颌下肿块且近期增大而就诊一年:颈部超声(US)和计算机断层扫描(CT)显示,右侧腮腺有一个圆形肿块,最大直径为3.1厘米。手术切除了肿块。组织病理学检查显示,肿瘤上皮呈特征性双层,淋巴基质突出,提示为 WT。此外,形态学和免疫组化研究证实了 MCL 同时存在。此后,该病例的最终诊断为 WT 并发 MCL:经过临床评估,患者被分期为 I 期。由于腮腺病变生长缓慢,因此决定密切观察,定期进行临床和放射学监测:目前,临床评估显示患者病情稳定:据我们所知,WT并发MCL的病例报道非常罕见。本病例强调了全面评估WT淋巴基质的重要性,以避免漏诊碰撞性肿瘤中的淋巴瘤成分。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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