Complicated role of ALKBH5 in gastrointestinal cancer: an updated review.

IF 5.3 2区医学 Q1 ONCOLOGY

Cancer Cell International Pub Date : 2024-08-24 DOI:10.1186/s12935-024-03480-5

Weitong Shu, Qianying Huang, Rui Chen, Huatao Lan, Luxin Yu, Kai Cui, Wanjun He, Songshan Zhu, Mei Chen, Li Li, Dan Jiang, Guangxian Xu

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Abstract

Gastrointestinal cancer is the most common malignancy in humans, often accompanied by poor prognosis. N6-methyladenosine (m6A) modification is widely present in eukaryotic cells as the most abundant RNA modification. It plays a crucial role in RNA splicing and processing, nuclear export, translation, and stability. Human AlkB homolog 5 (ALKBH5) is a type of RNA demethylase exhibiting abnormal expression in various gastrointestinal cancers.It is closely related to the tumorigenesis, proliferation, migration, and other biological functions of gastrointestinal cancer. However, recent studies indicated that the role and mechanism of ALKBH5 in gastrointestinal cancer are complicated and even controversial. Thus, this review summarizes recent advances in elucidating the role of ALKBH5 as a tumor suppressor or promoter in gastrointestinal cancer. It examines the biological functions of ALKBH5 and its potential as a therapeutic target, providing new perspectives and insights for gastrointestinal cancer research.

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ALKBH5 在胃肠癌中的复杂作用：最新综述。

胃肠癌是人类最常见的恶性肿瘤，通常预后不良。N6-甲基腺苷（m6A）修饰作为最丰富的 RNA 修饰广泛存在于真核细胞中。它在 RNA 剪接和加工、核输出、翻译和稳定性方面起着至关重要的作用。人类 AlkB 同源物 5（ALKBH5）是一种 RNA 去甲基化酶，在多种胃肠道癌症中表现出异常表达，与胃肠道癌症的肿瘤发生、增殖、迁移等生物学功能密切相关。然而，近年来的研究表明，ALKBH5 在胃肠癌中的作用和机制十分复杂，甚至存在争议。因此，本综述总结了阐明 ALKBH5 在胃肠癌中作为肿瘤抑制因子或促进因子的作用的最新进展。它探讨了 ALKBH5 的生物学功能及其作为治疗靶点的潜力，为胃肠癌研究提供了新的视角和见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Cell International ONCOLOGY-

CiteScore

10.90

自引率

1.70%

发文量

360

审稿时长

1 months

期刊介绍： Cancer Cell International publishes articles on all aspects of cancer cell biology, originating largely from, but not limited to, work using cell culture techniques. The journal focuses on novel cancer studies reporting data from biological experiments performed on cells grown in vitro, in two- or three-dimensional systems, and/or in vivo (animal experiments). These types of experiments have provided crucial data in many fields, from cell proliferation and transformation, to epithelial-mesenchymal interaction, to apoptosis, and host immune response to tumors. Cancer Cell International also considers articles that focus on novel technologies or novel pathways in molecular analysis and on epidemiological studies that may affect patient care, as well as articles reporting translational cancer research studies where in vitro discoveries are bridged to the clinic. As such, the journal is interested in laboratory and animal studies reporting on novel biomarkers of tumor progression and response to therapy and on their applicability to human cancers.

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