Impact of transcranial electrical stimulation on simultaneous stereoelectroencephalography recordings: A randomized sham-controlled study

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology Pub Date : 2024-08-14 DOI:10.1016/j.clinph.2024.08.003

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引用次数: 0

Abstract

Objective

Clinical exploitation of transcranial electrical stimulation for focal epilepsy treatment lacks quantification of the underlying neurophysiological changes. This study explores the immediate effects of transcranial alternating (tACS) and direct (tDCS) current stimulation on local and network brain activity using simultaneous stereoelectroencephalography (SEEG) recordings.

Methods

Patients were randomized for personalized tACS (n = 5) or tDCS (n = 6). Active stimulation (20 min) was preceded by sham stimulation (20 min). Changes in interictal epileptiform discharges (IED), functional connectivity (FC) and power spectral density (PSD) were quantified against baseline.

Results

Results demonstrated variable responses. Spike rate decreased in 2/6 subjects following sham and tDCS, while 2/6 showed an increase. Alpha power and aperiodic PSD components generally increased during and after tDCS but decreased following tACS. FC changes varied among subjects and were detectable even during sham sessions.

Conclusions

Strong variability suggests that tES does not have a univocal effect on immediate changes in IED or FC, possibly due to the single session format and challenges in affecting subcortical areas.

Significance

This is the first study to examine intracranial FC changes during tACS and tDCS, highlighting the importance of sham comparisons and individual variability in tES response, offering valuable insights into its application for epilepsy treatment.

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经颅电刺激对同步立体脑电图记录的影响：随机假对照研究

目的临床利用经颅电刺激治疗局灶性癫痫缺乏对潜在神经生理学变化的量化研究。本研究通过同步立体脑电图（SEEG）记录，探讨经颅交变电流刺激（tACS）和直流电流刺激（tDCS）对局部和网络大脑活动的直接影响。在主动刺激（20 分钟）之前进行假刺激（20 分钟）。对发作间期痫样放电 (IED)、功能连接性 (FC) 和功率谱密度 (PSD) 与基线的变化进行量化。在假性和 tDCS 治疗后，2/6 的受试者尖峰率下降，2/6 的受试者尖峰率上升。α功率和非周期性 PSD 成分在 tDCS 期间和之后普遍上升，但在 tACS 之后下降。FC的变化因受试者而异，即使在假疗程中也能检测到。结论强烈的变异性表明，tES对IED或FC的即时变化没有明确的影响，这可能是由于单次疗程的形式和影响皮层下区域的挑战所致。意义这是第一项检查tACS和tDCS期间颅内FC变化的研究，强调了假对比的重要性和tES反应的个体变异性，为其在癫痫治疗中的应用提供了宝贵的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.