Antimicrobial activity of the LTA zeolite modified by zinc species

IF 4.8 3区材料科学 Q1 CHEMISTRY, APPLIED

Microporous and Mesoporous Materials Pub Date : 2024-08-12 DOI:10.1016/j.micromeso.2024.113295

Jesús Isaías De León Ramirez , Víctor Alfredo Reyes Villegas , Ruben D. Cadena-Nava , Elizabeth Loredo-Garcia , Fernando Chávez-Rivas , Verónica González-Torres , Vitalii Petranovskii

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Abstract

Metal species supported on zeolites have proven efficient synergistic mechanisms against microorganisms, reducing the overall toxicity. Likewise, the deposition of metals by ultrasound is a method that has drawn attention due to its efficiency, low cost, and environmental friendliness. Hence, the antimicrobial properties of Zinc (Zn) species supported on LTA zeolite (NaA) via a sono-assisted method were explored in this study. Zeolite A modified with Zn species by ion exchange or sono-assisted precipitation of active Zn species (Zn(OH)₂, ZnO, and ZnO₂) was evaluated in a screening experiment by agar diffusion and micro broth assays. Finding that at a concentration of 30 mg/mL, drying the ZnO₂@NaA material activated a mechanism that inhibited the growth of E. faecalis by 100 % while eliminating the drying step, an inverse effect was produced, now inhibiting the growth of E. coli. This sample also presented promising properties as an antimycotic agent inhibiting the growth of C. albicans by 90 % at a concentration of 1 mg/mL. In addition, a viability analysis was performed on fibroblasts, demonstrating a potential toxicity reduction.

This ZnO₂@NaA material holds promise as an antibacterial and antifungal agent. Presenting a novel sono-assisted methodology for tuning the selectivity of inhibition mechanisms for peroxide-containing species in zeolites. This selected zinc-containing zeolitic material (ZnO₂@NaA) was then characterized by UV–Vis, FTIR, Raman spectroscopy SEM, XRD, and ζ-potential, evidencing the presence of ZnO₂ nanoparticles. This study opens perspectives for developing new antimicrobial Zn-containing zeolitic materials through a sono-assisted methodology for increasing selectivity in the inhibition mechanisms.

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锌物种修饰的 LTA 沸石的抗菌活性

事实证明，沸石上支持的金属物种可以有效地协同对抗微生物，降低整体毒性。同样，通过超声沉积金属的方法也因其高效、低成本和环保而备受关注。因此，本研究探讨了通过超声辅助方法在 LTA 沸石（NaA）上支持锌（Zn）物种的抗菌特性。通过离子交换或声波辅助沉淀活性锌物种（Zn(OH)2、ZnO 和 ZnO2），用锌物种修饰沸石 A，并通过琼脂扩散和微肉汤试验进行了筛选评估。结果发现，在浓度为 30 毫克/毫升时，干燥 ZnO2@NaA 材料可激活一种机制，100% 地抑制粪肠球菌的生长，而取消干燥步骤则会产生反向效应，现在可抑制大肠杆菌的生长。该样品还具有抗霉菌剂的良好特性，在 1 毫克/毫升的浓度下可抑制白僵菌生长 90%。此外，还对成纤维细胞进行了存活率分析，显示出潜在的毒性降低作用。这种 ZnO2@NaA 材料有望用作抗菌剂和抗真菌剂。介绍一种新型声波辅助方法，用于调整沸石中含过氧化物物种抑制机制的选择性。然后通过紫外-可见光、傅立叶变换红外光谱、拉曼光谱、扫描电镜、X射线衍射和ζ电位对这种选定的含锌沸石材料（ZnO2@NaA）进行了表征，证明了 ZnO2 纳米颗粒的存在。这项研究为通过声波辅助方法开发新型含锌沸石抗菌材料以提高抑制机制的选择性开辟了前景。

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来源期刊

Microporous and Mesoporous Materials 化学-材料科学：综合

CiteScore

10.70

自引率

5.80%

发文量

649

审稿时长

26 days

期刊介绍： Microporous and Mesoporous Materials covers novel and significant aspects of porous solids classified as either microporous (pore size up to 2 nm) or mesoporous (pore size 2 to 50 nm). The porosity should have a specific impact on the material properties or application. Typical examples are zeolites and zeolite-like materials, pillared materials, clathrasils and clathrates, carbon molecular sieves, ordered mesoporous materials, organic/inorganic porous hybrid materials, or porous metal oxides. Both natural and synthetic porous materials are within the scope of the journal. Topics which are particularly of interest include: All aspects of natural microporous and mesoporous solids The synthesis of crystalline or amorphous porous materials The physico-chemical characterization of microporous and mesoporous solids, especially spectroscopic and microscopic The modification of microporous and mesoporous solids, for example by ion exchange or solid-state reactions All topics related to diffusion of mobile species in the pores of microporous and mesoporous materials Adsorption (and other separation techniques) using microporous or mesoporous adsorbents Catalysis by microporous and mesoporous materials Host/guest interactions Theoretical chemistry and modelling of host/guest interactions All topics related to the application of microporous and mesoporous materials in industrial catalysis, separation technology, environmental protection, electrochemistry, membranes, sensors, optical devices, etc.