Bed nucleus of the stria terminalis network responses to unpredictable threat in early alcohol abstinence

IF 3 Q2 SUBSTANCE ABUSE
Nicole L. Zabik, Elizabeth A. Flook, Brandee Feola, Margaret M. Benningfield, Marisa M. Silveri, Danny G. Winder, Jennifer Urbano Blackford
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引用次数: 0

Abstract

Background

Anxiety during early alcohol abstinence, likely resulting from neural changes caused by chronic alcohol use, contributes to high relapse rates. Studies in rodents show heightened activation during early abstinence in the bed nucleus of the stria terminalis (BNST)—a neural hub for anxiety—and its extended anxiety-related corticolimbic network. Despite the clinical importance of early abstinence, few studies investigate the underlying neural mechanisms.

Methods

To address this gap, we investigated brain function in early alcohol abstinence (EA = 20, 9 women) relative to controls (HC = 20, 11 women) using an unpredictable threat task shown to engage the BNST and corticolimbic brain regions involved in anxiety and alcohol use disorder (AUD). Group, anxiety, and sex were predictors used to determine whole-brain activation and BNST functional connectivity.

Results

We found widespread interactions of group × anxiety and group × anxiety × sex for both activation and BNST connectivity during unpredictable threat. In the EA group, higher anxiety was correlated with activation in the BNST, rostral anterior cingulate cortex (ACC), insula (men only), and dorsal ACC (men only). In the HC group, higher anxiety was negatively correlated with activation in the BNST, nucleus accumbens, thalamus, and insula (men only). For connectivity, anxiety was positively correlated in EA and negatively correlated in HC, between the BNST and the amygdala, ventromedial prefrontal cortex (PFC), and dorsomedial PFC; EA men showed stronger BNST-vmPFC connectivity than HC men.

Conclusions

These novel findings provide preliminary evidence for alterations in the BNST and anxiety-related corticolimbic brain regions in early alcohol abstinence, adding to growing literature in humans supporting the BNST's role in anxiety and sex-dependent effects of chronic alcohol use.

Abstract Image

Abstract Image

戒酒早期纹状体末端床核网络对不可预测威胁的反应
背景:早期戒酒期间的焦虑可能是由长期饮酒引起的神经变化造成的,这也是导致高复发率的原因之一。对啮齿类动物的研究表明,在早期戒酒期间,作为焦虑神经中枢的纹状体末端床核(BNST)及其扩展的焦虑相关皮质边缘网络的激活增强。尽管早期戒断具有重要的临床意义,但很少有研究调查其潜在的神经机制:为了填补这一空白,我们利用一项不可预测的威胁任务,研究了早期戒酒者(EA = 20 人,9 名女性)相对于对照组(HC = 20 人,11 名女性)的大脑功能,该任务显示了 BNST 和皮质边缘脑区参与焦虑和酒精使用障碍(AUD)。组别、焦虑和性别是用于确定全脑激活和 BNST 功能连接的预测因子:结果:我们发现,在不可预测的威胁下,组别×焦虑和组别×焦虑×性别对激活和 BNST 连接具有广泛的交互作用。在 EA 组,较高的焦虑与 BNST、喙状前扣带回皮层 (ACC)、脑岛(仅男性)和背侧 ACC(仅男性)的激活相关。在高危人群组中,较高的焦虑与 BNST、伏隔核、丘脑和脑岛(仅男性)的激活呈负相关。在连通性方面,EA 组的焦虑与 BNST 和杏仁核、腹外侧前额叶皮层 (PFC) 以及背内侧前额叶皮层之间呈正相关,而 HC 组则呈负相关;EA 组男性比 HC 组男性表现出更强的 BNST-vmPFC 连通性:这些新发现提供了初步证据,证明在早期戒酒过程中,BNST和焦虑相关的皮质边缘脑区发生了改变,为越来越多的人类文献支持BNST在焦虑和长期饮酒的性别依赖效应中的作用增添了新的内容。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
5.40
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