Expression analysis of SOX2 and SOX9 in patients with oral squamous cell carcinoma.

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-08-23 DOI:10.1002/hed.27925

Sonja Steen, Dominik Horn, Christa Flechtenmacher, Jürgen Hoffmann, Kolja Freier, Oliver Ristow, Jochen Hess, Julius Moratin

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引用次数: 0

Abstract

Background: Lately SOX2 and SOX9, transcription factors associated with stemness-like phenotypes of cancer cells, have been linked to tumor growth, metastasis, and resistance to therapy.

Methods: This study aimed on evaluating the expression of SOX2 and SOX9 in a large cohort of patients with OSCC including primary and recurrent tumors and corresponding lymph node metastases. Semiautomatic digital pathology scoring was used to determine protein expression and survival analysis was performed to evaluate its prognostic significance.

Results: We found a significant downregulation of SOX9 from primary disease to lymph node metastases (p < 0.001). SOX9 expression and the subgroup SOX2^lowSOX9^high were significantly correlated with worse overall survival (p < 0.05). Additionally, SOX2^lowSOX9^high expression pattern was confirmed as independent prognosticator for overall survival.

Conclusions: These results indicate the relevant role of SOX2 and SOX9 in patients with OSCC and show the clinical relevance for further investigation on the molecular mechanisms underlying SOX-related gene expression.

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口腔鳞状细胞癌患者中 SOX2 和 SOX9 的表达分析。

背景：SOX2和SOX9是与癌细胞干性表型相关的转录因子：最近，与癌细胞干性表型相关的转录因子SOX2和SOX9与肿瘤生长、转移和抗药性有关：本研究旨在评估SOX2和SOX9在一大批OSCC患者（包括原发性和复发性肿瘤以及相应的淋巴结转移灶）中的表达情况。采用半自动数字病理评分法确定蛋白表达，并进行生存分析以评估其预后意义：结果：我们发现，从原发疾病到淋巴结转移，SOX9均出现了明显的下调（p lowSOX9high与总生存期的恶化显著相关（p lowSOX9high表达模式被证实为总生存期的独立预后因子）：这些结果表明了SOX2和SOX9在OSCC患者中的相关作用，并显示了进一步研究SOX相关基因表达的分子机制的临床意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.