Association between ultra-processed food and osteoporosis: a cross-sectional study based on the NHANES database.

IF 3.9 2区医学 Q2 NUTRITION & DIETETICS

Nutrition & Metabolism Pub Date : 2024-08-23 DOI:10.1186/s12986-024-00843-7

Songfeng Wang, Jiasi Xie, Dandan Zhai, Zhou Wang, Huixuan Qi, Muhong Deng

{"title":"Association between ultra-processed food and osteoporosis: a cross-sectional study based on the NHANES database.","authors":"Songfeng Wang, Jiasi Xie, Dandan Zhai, Zhou Wang, Huixuan Qi, Muhong Deng","doi":"10.1186/s12986-024-00843-7","DOIUrl":null,"url":null,"abstract":"Aim: Nutritional characteristics and additives in ultra-processed foods (UPF) are directly related to bone health. Physical activity as a modifiable lifestyle intervention also plays a possible role in bone mineral density (BMD), but effect of physical activity on association between UPF and osteoporosis is not fully understood. Herein, this study aims to explore the association of UPF with osteoporosis, and assess the potential mediating effects of some related factors on this pathway.Methods: Data of adults were extracted from the National Health and Nutrition Examination Survey (NHANES) database in this cross-sectional study. Associations of unprocessed/minimally processed food (MPF), processed culinary ingredient (PCI), processed foods (PF) and UPF with femur neck BMD, total femur BMD and osteoporosis were investigated using linear regression and weighted univariate and multivariate logistic regression analyses respectively. Subgroup analyses of age, gender, physical activity, poverty income ratio (PIR), hypertension, diabetes mellitus (DM), cardiovascular disease (CVD), and dyslipidemia were performed. The potential mediating and interaction effects of physical activity and related factors on association of UPF with osteoporosis were also assessed. The evaluation indexes were β, odds ratios (ORs) and 95% confidence intervals (CIs).Results: Among 10,678 eligible persons, 454 had osteoporosis. After adjusting for covariates, elevated UPF intake was associated with decreased demur neck and total femur BMD (β=-0.003). A higher UPF intake level (> 57.51%) was linked to higher odds of osteoporosis (OR = 1.789). These relationships were also significant in different subgroups. Physical activity had a potential mediating effect on the association between UPF and osteoporosis (OR = 0.47, mediating proportion = 21.54%).Conclusion: UPF intake levels were associated with BMD and osteoporosis. Physical activity had an interaction effect with UPF, and had a potential mediating effect on relationship between UPF and osteoporosis.","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":null,"pages":null},"PeriodicalIF":3.9000,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11342598/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrition & Metabolism","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12986-024-00843-7","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}

引用次数: 0

Abstract

Aim: Nutritional characteristics and additives in ultra-processed foods (UPF) are directly related to bone health. Physical activity as a modifiable lifestyle intervention also plays a possible role in bone mineral density (BMD), but effect of physical activity on association between UPF and osteoporosis is not fully understood. Herein, this study aims to explore the association of UPF with osteoporosis, and assess the potential mediating effects of some related factors on this pathway.

Methods: Data of adults were extracted from the National Health and Nutrition Examination Survey (NHANES) database in this cross-sectional study. Associations of unprocessed/minimally processed food (MPF), processed culinary ingredient (PCI), processed foods (PF) and UPF with femur neck BMD, total femur BMD and osteoporosis were investigated using linear regression and weighted univariate and multivariate logistic regression analyses respectively. Subgroup analyses of age, gender, physical activity, poverty income ratio (PIR), hypertension, diabetes mellitus (DM), cardiovascular disease (CVD), and dyslipidemia were performed. The potential mediating and interaction effects of physical activity and related factors on association of UPF with osteoporosis were also assessed. The evaluation indexes were β, odds ratios (ORs) and 95% confidence intervals (CIs).

Results: Among 10,678 eligible persons, 454 had osteoporosis. After adjusting for covariates, elevated UPF intake was associated with decreased demur neck and total femur BMD (β=-0.003). A higher UPF intake level (> 57.51%) was linked to higher odds of osteoporosis (OR = 1.789). These relationships were also significant in different subgroups. Physical activity had a potential mediating effect on the association between UPF and osteoporosis (OR = 0.47, mediating proportion = 21.54%).

Conclusion: UPF intake levels were associated with BMD and osteoporosis. Physical activity had an interaction effect with UPF, and had a potential mediating effect on relationship between UPF and osteoporosis.

查看原文本刊更多论文

超标加工食品与骨质疏松症之间的关系：基于 NHANES 数据库的横断面研究。

目的：超加工食品（UPF）中的营养特性和添加剂与骨骼健康直接相关。体育锻炼作为一种可改变的生活方式干预措施，也可能对骨矿物质密度（BMD）起作用，但体育锻炼对 UPF 与骨质疏松症之间关系的影响尚不完全清楚。本研究旨在探讨 UPF 与骨质疏松症的关系，并评估一些相关因素对这一途径的潜在中介作用：这项横断面研究从美国国家健康与营养调查（NHANES）数据库中提取了成人数据。采用线性回归和加权单变量及多变量逻辑回归分析，分别研究了未加工/微加工食品（MPF）、加工烹饪配料（PCI）、加工食品（PF）和 UPF 与股骨颈 BMD、股骨总 BMD 和骨质疏松症的关系。对年龄、性别、体力活动、贫困收入比（PIR）、高血压、糖尿病（DM）、心血管疾病（CVD）和血脂异常进行了分组分析。此外，还评估了体力活动和相关因素对 UPF 与骨质疏松症之间关系的潜在中介效应和交互效应。评价指标为β、几率比（ORs）和95%置信区间（CIs）：在符合条件的 10 678 人中，454 人患有骨质疏松症。在对相关因素进行调整后，UPF 摄入量的增加与股骨颈和总股骨 BMD 的减少有关（β=-0.003）。较高的 UPF 摄入水平（> 57.51%）与较高的骨质疏松症几率有关（OR = 1.789）。这些关系在不同的亚组中也很明显。体育锻炼对 UPF 与骨质疏松症之间的关系具有潜在的中介效应（OR = 0.47，中介比例 = 21.54%）：结论：UPF 摄入水平与 BMD 和骨质疏松症有关。结论：UPF 摄入水平与 BMD 和骨质疏松症有关，体育锻炼与 UPF 有交互效应，并对 UPF 与骨质疏松症之间的关系有潜在的中介效应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nutrition & Metabolism 医学-营养学

CiteScore

8.40

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Nutrition & Metabolism publishes studies with a clear focus on nutrition and metabolism with applications ranging from nutrition needs, exercise physiology, clinical and population studies, as well as the underlying mechanisms in these aspects. The areas of interest for Nutrition & Metabolism encompass studies in molecular nutrition in the context of obesity, diabetes, lipedemias, metabolic syndrome and exercise physiology. Manuscripts related to molecular, cellular and human metabolism, nutrient sensing and nutrient–gene interactions are also in interest, as are submissions that have employed new and innovative strategies like metabolomics/lipidomics or other omic-based biomarkers to predict nutritional status and metabolic diseases. Key areas we wish to encourage submissions from include: -how diet and specific nutrients interact with genes, proteins or metabolites to influence metabolic phenotypes and disease outcomes; -the role of epigenetic factors and the microbiome in the pathogenesis of metabolic diseases and their influence on metabolic responses to diet and food components; -how diet and other environmental factors affect epigenetics and microbiota; the extent to which genetic and nongenetic factors modify personal metabolic responses to diet and food compositions and the mechanisms involved; -how specific biologic networks and nutrient sensing mechanisms attribute to metabolic variability.